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Title: The -844 G/A PAI-1 polymorphism is associated with mRNA expression in rheumatoid arthritis
Author: Torres-Carrillo, N.M.
Torres-Carrillo, N.
Vazquez-Del Mercado, M.
Delgado-Rizo, V.
Oregon-Romero, E.
Parra-Rojas, I.
Munoz-Valle, J.F.
Issue Date: 2008
Abstract: We assessed whether the -844 G/A polymorphism and mRNA expression of plasminogen activator inhibitor 1 (PAI-1) gene are associated with rheumatoid arthritis (RA). Demographic data, hematological, biochemical parameters, disease activity-disability indexes, -844 G/A genotypes and mRNA expression levels of the PAI-1 gene were determined in 50 RA patients and 50 healthy subjects (HS). Non-significant differences in genotype and allele frequencies related to -844 G/A polymorphism in RA versus HS, were found. High mRNA expression of the PAI-1 gene, was demonstrated in RA versus HS (P < 0.05). In addition, A/A genotype carriers showed increase of PAI-1 mRNA expression (3.1-fold) respect to G/G and G/A genotypes in RA patients (P < 0.05). Our finding suggest an association of A/A -844 PAI-1 genotype with high PAI-1 mRNA expression in RA patients. © 2007 Springer-Verlag.
Appears in Collections:Producción científica UdeG (prueba)

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