Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/70749
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dc.contributor.authorPalafox Sanchez, C.A.
dc.contributor.authorSatoh, M.
dc.contributor.authorChan, E.K.
dc.contributor.authorCarcamo, W.C.
dc.contributor.authorMunoz Valle, J.F.
dc.contributor.authorOrozco Barocio, G.
dc.contributor.authorOregon Romero, E.
dc.contributor.authorNavarro Hernandez, R.E.
dc.contributor.authorSalazar Paramo, M.
dc.contributor.authorCabral Castaneda, A.
dc.contributor.authorVazquez Del Mercado, M.
dc.date.accessioned2015-11-19T18:57:23Z-
dc.date.available2015-11-19T18:57:23Z-
dc.date.issued2009
dc.identifier.urihttp://hdl.handle.net/20.500.12104/70749-
dc.description.abstractINTRODUCTION: Systemic lupus erythematosus is characterized by production of autoantibodies to RNA or DNA-protein complexes such as small nuclear ribonucleoproteins (snRNPs). A role of Epstein-Barr virus in the pathogenesis has been suggested. Similar to Epstein-Barr virus, cytomegalovirus (CMV) infects the majority of individuals at a young age and establishes latency with a potential for reactivation. Homology of CMV glycoprotein B (UL55) with the U1snRNP-70 kDa protein (U1-70 k) has been described; however, the role of CMV infection in production of anti-snRNPs is controversial. We investigated the association of CMV serology and autoantibodies in systemic lupus erythematosus. METHODS: Sixty-one Mexican patients with systemic lupus erythematosus were tested for CMV and Epstein-Barr virus serology (viral capsid antigen, IgG, IgM) and autoantibodies by immunoprecipitation and ELISA (IgG and IgM class, U1RNP/Sm, U1-70 k, P peptide, rheumatoid factor, dsDNA, beta2-glycoprotein I). RESULTS: IgG anti-CMV and IgM anti-CMV were positive in 95% (58/61) and 33% (20/61), respectively, and two cases were negative for both. Clinical manifestation and autoantibodies in the IgM anti-CMV+ group (n = 20) versus the IgM anti-CMV(-)IgG+ (n = 39) group were compared. Most (19/20) of the IgM anti-CMV+ cases were IgG anti-CMV+, consistent with reactivation or reinfection. IgM anti-CMV was unrelated to rheumatoid factor or IgM class autoantibodies and none was positive for IgM anti-Epstein-Barr virus-viral capsid antigen, indicating that this is not simply due to false positive results caused by rheumatoid factor or nonspecific binding by certain IgM. The IgM anti-CMV+ group has significantly lower levels of IgG anti-U1RNP/Sm and IgG anti-U1-70 k (P = 0.0004 and P = 0.0046, respectively). This finding was also confirmed by immunoprecipitation. Among the IgM anti-CMV(-) subset, anti-Su was associated with anti-U1RNP and anti-Ro (P < 0.05). High levels of IgG anti-CMV were associated with production of lupus-related autoantibodies to RNA or DNA-protein complex (P = 0.0077). CONCLUSIONS : Our findings suggest a potential role of CMV in regulation of autoantibodies to snRNPs and may provide a unique insight to understand the pathogenesis.
dc.titleReduced IgG anti-small nuclear ribonucleoprotein autoantibody production in systemic lupus erythematosus patients with positive IgM anti-cytomegalovirus antibodies.
dc.typeArticle
dc.relation.ispartofjournalArthritis research & therapy
dc.relation.ispartofvolume11
dc.relation.ispartofissue1
dc.contributor.affiliationPalafox Sánchez, C.A., Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético (IIRSME), Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada 950, Guadalajara, Jalisco, CP 44340, México.; Satoh, M., Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético (IIRSME), Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada 950, Guadalajara, Jalisco, CP 44340, México.; Chan, E.K., Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético (IIRSME), Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada 950, Guadalajara, Jalisco, CP 44340, México.; Carcamo, W.C., Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético (IIRSME), Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada 950, Guadalajara, Jalisco, CP 44340, México.; Muñoz Valle, J.F., Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético (IIRSME), Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada 950, Guadalajara, Jalisco, CP 44340, México.; Orozco Barocio, G., Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético (IIRSME), Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada 950, Guadalajara, Jalisco, CP 44340, México.; Oregon Romero, E., Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético (IIRSME), Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada 950, Guadalajara, Jalisco, CP 44340, México.; Navarro Hernández, R.E., Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético (IIRSME), Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada 950, Guadalajara, Jalisco, CP 44340, México.; Salazar Páramo, M., Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético (IIRSME), Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada 950, Guadalajara, Jalisco, CP 44340, México.; Cabral Castañeda, A., Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético (IIRSME), Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada 950, Guadalajara, Jalisco, CP 44340, México.; Vázquez Del Mercado, M., Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético (IIRSME), Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada 950, Guadalajara, Jalisco, CP 44340, México.
dc.subject.headingIndex Medicus;Adult;Antibodies/bl [Blood];Antibodies/im [Immunology];Antibodies, Viral/bl [Blood];Antigens, Viral/im [Immunology];Autoantibodies/bl [Blood];Autoantibodies/im [Immunology];Autoantigens/bl [Blood];Autoantigens/im [Immunology];Cytomegalovirus Infections/bl [Blood];Cytomegalovirus Infections/im [Immunology];Enzyme-Linked Immunosorbent Assay;Epstein-Barr Virus Infections/bl [Blood];Epstein-Barr Virus Infections/im [Immunology];Female;Humans;Immunoglobulin G/bl [Blood];Immunoglobulin G/im [Immunology];Immunoglobulin M/bl [Blood];Immunoglobulin M/im [Immunology];Immunoprecipitation;Lupus Erythematosus, Systemic/bl [Blood];Lupus Erythematosus, Systemic/im [Immunology];Lupus Erythematosus, Systemic/vi [Virology];Male;Ribonucleoproteins, Small Nuclear/im [Immunology]
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