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Title: Serum concentrations of aminoterminal propeptide of type III procollagen and propeptide of human type I procollagen in systemic lupus erythematosus
Author: Villa-Manzano, A.I.
Gamez-Nava, J.I.
Salazar-Paramo, M.
Valera-Gonzalez, I.C.
Garcia-Gonzalez, A.
Garcia-Gonzalez, G.
Morales-Romero, J.
Lopez-Olivo, A.
Galvan-Ramirez, L.M.
Ruiz-Ruvalcaba, R.
Cardona-Munoz, E.G.
Gonzalez-Lopez, L.
Issue Date: 2006
Abstract: The purpose of this study was to assess the association between the serum levels of aminoterminal propeptide of type III procollagen (PIIINP) and carboxyterminal propeptide of type I procollagen (PICP) with disease activity and damage in systemic lupus erythematosus (SLE). Thirty-three patients with SLE were compared with 31 controls. The assessment in SLE included disease activity indices (SLEDAI, MEX-SLEDAI) and damage index (SLICC/ACR). PIIINP and PICP were measured by radioimmunoassay. Compared with controls, mean levels of PIIINP were higher in SLE (2.9 ± 1.8 vs. 1.8 ± 1.2, P = 0.006). PICP was also increased in SLE versus controls (163 ± 94 vs. 102 ± 62, P = 0.007). PIIINP was correlated with SLICC/ACR (r = 0.33, P = 0.048). No correlation was observed between PICP and PIIINP with other clinical or therapeutic variables. These preliminary data suggests a role of PIIINP as a marker for chronic damage. Follow-up studies are required to evaluate its utility in predicting future damage. © Springer-Verlag 2005.
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