Please use this identifier to cite or link to this item:
|Title:||Procollagen Type I and III Aminoterminal Propeptide Levels and Severity of Interstitial Lung Disease in Mexican Women With Progressive Systemic Sclerosis|
Vazquez-del Mercado, M.
|Abstract:||Background: Interstitial lung disease (ILD) is a frequent complication in progressive systemic sclerosis (SSc), being present in 25% to 90% of cases. Objectives: To evaluate whether serum levels of procollagen type. i and iii aminoterminal propeptide (PINP and PIIINP) correlate with severity and patterns of ILD in Mexican women with SSc. Methods: Thirty three SSc patients were assessed for disease characteristics and anti-topoisomerase antibodies (topo. i), and also underwent pulmonary function tests and high-resolution computed tomography (HRCT). Nineteen patients had ILD + SSc, and 14 had no lung involvement (no ILD-SSc); data were compared with those from 45 healthy controls. PINP and PIIINP were assessed in all 3 groups. Results: Patients with SSc had higher PINP and PIIINP vs controls (P = 001, P < .001, respectively). Compared to no ILD-SSc patients, those with ILD + SSc had longer disease duration in years (P = .005), higher modified Rodnan skin score (P < 001), higher Health Assessment Questionnaire-Disability-Index scores (P < 001), higher topo. i U/mL (P < 001), PINP (49.28 ± 28.63 vs. 32.12 ± 18.58 μg/L, P = 05), and PIIINP (4.33 ± 1.03 vs. 2.67 ± 1.26 μg/L, P < 001) levels. ILD severity based on total HRCT correlated with PINP (r = 388, P = 03) and PIIINP (P = 594, P < 001). On adjusted analysis, ILD severity was associated with disease duration (P = 037), PIIINP (P = 038), and topo. i ( P = 045). Conclusions: PINP and PIIINP are useful markers for severe ILD. +. SSc, suggesting they could play a role in the follow-up of this complication in SSc. © 2014 SEPAR.|
|Appears in Collections:||Producción científica UdeG (prueba)|
Files in This Item:
There are no files associated with this item.
Items in RIUdeG are protected by copyright, with all rights reserved, unless otherwise indicated.