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Title: Procollagen Type I and III Aminoterminal Propeptide Levels and Severity of Interstitial Lung Disease in Mexican Women With Progressive Systemic Sclerosis
Author: Gonzalez-Lopez, L.
Rocha-Munoz, A.D.
Olivas-Flores, E.M.
Garcia-Gonzalez, A.
Peguero-Gomez, A.R.
Flores-Navarro, J.
Villa-Manzano, A.I.
Zavaleta-Muniz, S.A.
Salazar-Paramo, M.
Mejia, M.
Juarez-Contreras, P.
Vazquez-del Mercado, M.
Cardona-Munoz, E.G.
Trujillo-Hernandez, B.
Nava-Zavala, A.H.
Gamez-Nava, J.I.
Issue Date: 2014
Abstract: Background: Interstitial lung disease (ILD) is a frequent complication in progressive systemic sclerosis (SSc), being present in 25% to 90% of cases. Objectives: To evaluate whether serum levels of procollagen type. i and iii aminoterminal propeptide (PINP and PIIINP) correlate with severity and patterns of ILD in Mexican women with SSc. Methods: Thirty three SSc patients were assessed for disease characteristics and anti-topoisomerase antibodies (topo. i), and also underwent pulmonary function tests and high-resolution computed tomography (HRCT). Nineteen patients had ILD + SSc, and 14 had no lung involvement (no ILD-SSc); data were compared with those from 45 healthy controls. PINP and PIIINP were assessed in all 3 groups. Results: Patients with SSc had higher PINP and PIIINP vs controls (P = 001, P < .001, respectively). Compared to no ILD-SSc patients, those with ILD + SSc had longer disease duration in years (P = .005), higher modified Rodnan skin score (P < 001), higher Health Assessment Questionnaire-Disability-Index scores (P < 001), higher topo. i U/mL (P < 001), PINP (49.28 ± 28.63 vs. 32.12 ± 18.58 μg/L, P = 05), and PIIINP (4.33 ± 1.03 vs. 2.67 ± 1.26 μg/L, P < 001) levels. ILD severity based on total HRCT correlated with PINP (r = 388, P = 03) and PIIINP (P = 594, P < 001). On adjusted analysis, ILD severity was associated with disease duration (P = 037), PIIINP (P = 038), and topo. i ( P = 045). Conclusions: PINP and PIIINP are useful markers for severe ILD. +. SSc, suggesting they could play a role in the follow-up of this complication in SSc. © 2014 SEPAR.
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