Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/66917
Title: PGE2 alleviates kidney and liver damage, decreases plasma renin activity and acute phase response in cirrhotic rats with acute liver damage
Author: Rincon-Sanchez, A.R.
Covarrubias, A.
Rivas-Estilla, A.M.
Pedraza-Chaverri, J.
Cruz, C.
Islas-Carbajal, M.C.
Panduro-Cerda, Arturo
Estanes, A.
Armendariz-Borunda, J.
Issue Date: 2005
Abstract: In this study, we evaluated the effect of prostaglandin E2 (PGE2) on renal and hepatic function using an experimental cirrhosis model plus acute liver damage (ALD). Male Wistar rats treated with carbon tetrachloride (CCl4) for 8 weeks were used for the cirrhosis model. Cirrhotic rats were further exposed to an additional acute dose of CCl 4 to induce ALD and then treated with PGE2 intramuscularly twice a day for 7 days (200 μg/Kg/day). PGE2 administration started 3 h after the additional dosing of CCl4 and PGE2 effect on hepatorenal function was examined on days 1, 2, 3, and 7. PGE 2-treatment ameliorated the decrease in urinary sodium excretion, and normalized serum activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and plasma renin observed in cirrhotic rats with ALD. In addition, PGE2-treatment decreased mean arterial pressure, glomerular hypercellularity and thickening of the kidney capillary wall, and liver steatosis and cellular necrosis. Also, PGE2 increased the number of regenerative nodules. Finally, PGE2-treatment inhibited the increase in Alpha 1-acid glycoprotein (pAGP), fibrinogen, and Apo A-1 mRNA expression by 83%, 59%, and 77%, respectively. These results suggest that PGE2 administration may decrease the expression of acute phase proteins. In conclusion, PGE2-treatment improved hepatic and renal function and may be useful to down-regulate the acute phase response in cirrhotic rats presenting ALD induced by CCl4. © 2004 Elsevier GmbH. All rights reserved.
URI: http://hdl.handle.net/20.500.12104/66917
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