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Title: Oxidative stress is increased in serum from Mexican patients with relapsing-remitting multiple sclerosis
Author: Ortiz, G.G.
Macias-Islas, M.A.
Pacheco-Moises, F.P.
Cruz-Ramos, J.A.
Sustersik, S.
Barba, E.A.
Aguayo, A.
Issue Date: 2009
Abstract: Objective: To determine the oxidative stress markers in serum from patients with relapsing-remitting multiple sclerosis. Methods: Blood samples from healthy controls and 22 patients 15 women (7 aged from 20 to 30 and 8 were > 40 years old) and 7 men (5 aged from 20 to 30 and 2 were > 40 years old) fulfilling the McDonald Criteria and classified as having Relapsing-Remitting Multiple Sclerosis accordingly with Lublin were collected for oxidative stress markers quantification. Results: Nitric oxide metabolites (nitrates/nitrites), lipid peroxidation products (malondialdehyde plus 4-hidroxialkenals), and glutathione peroxidase activity were significantly increased in serum of subjects with relapsing-remitting multiple sclerosis in comparison with that of healthy controls. These data support the hypothesis that multiple sclerosis is a component closely linked to oxidative stress. © 2009 - IOS Press and the authors. All rights reserved.
Appears in Collections:Producción científica UdeG (prueba)

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