Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/66612
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dc.contributor.authorLoera-Castaneda, V.
dc.contributor.authorSandoval-Ramirez, L.
dc.contributor.authorPacheco Moises, F.P.
dc.contributor.authorMacias-Islas, M.A.
dc.contributor.authorAlatorre Jimenez, M.A.
dc.contributor.authorGonzalez-Renovato, E.D.
dc.contributor.authorCortes-Enriquez, F.
dc.contributor.authorCelis De La Rosa, A.
dc.contributor.authorVelazquez-Brizuela, I.E.
dc.contributor.authorOrtiz, G.G.
dc.date.accessioned2015-11-19T18:51:27Z-
dc.date.available2015-11-19T18:51:27Z-
dc.date.issued2014
dc.identifier.urihttp://hdl.handle.net/20.500.12104/66612-
dc.description.abstractMitochondrial dysfunction has been thought to contribute to Alzheimer disease (AD) pathogenesis through the accumulation of mitochondrial DNA mutations and net production of reactive oxygen species (ROS). Mitochondrial cytochrome c-oxidase plays a key role in the regulation of aerobic production of energy and is composed of 13 subunits. The 3 largest subunits (I, II, and III) forming the catalytic core are encoded by mitochondrial DNA. The aim of this work was to look for mutations in mitochondrial cytochrome c-oxidase gene II (MTCO II) in blood samples from probable AD Mexican patients. MTCO II gene was sequenced in 33 patients with diagnosis of probable AD. Four patients (12%) harbored the A8027G polymorphism and three of them were early onset (EO) AD cases with familial history of the disease. In addition, other four patients with EOAD had only one of the following point mutations: A8003C, T8082C, C8201T, or G7603A. Neither of the point mutations found in this work has been described previously for AD patients, and the A8027G polymorphism has been described previously; however, it hasn't been related to AD. We will need further investigation to demonstrate the role of the point mutations of mitochondrial DNA in the pathogenesis of AD. © 2014 Verónica Loera-Castañeda et al.
dc.titleNovel point mutations and A8027G polymorphism in mitochondrial-DNA-encoded cytochrome c Oxidase II gene in mexican patients with probable alzheimer disease
dc.typeArticle
dc.identifier.doi10.1155/2014/794530
dc.relation.ispartofjournalInternational Journal of Alzheimer's Disease
dc.relation.ispartofvolume2014
dc.relation.ispartofpage794530
dc.contributor.affiliationLoera-Castañeda, V., Laboratorio de Desarrollo-Envejecimiento: Enfermedades Neurodegenerativas, División de Neurociencias, Instituto Mexicano Del Seguro Social, Sierra Mojada No. 800, Colonia-Independencia 44340 Guadalajara, JAL, Mexico, Laboratorio de Farmacogenómica y Biomedicina Molecular, Centro Interdisciplinario de Investigación Para El Desarrollo Integral Regional, Instituto Politécnico Nacional, Unidad Durango, DGO, Mexico; Sandoval-Ramírez, L., Laboratorio de Bioquímica IV, División de Genética, Instituto Mexicano Del Seguro Social, Guadalajara, JAL, Mexico; Pacheco Moisés, F.P., Departamento de Química, Centro Universitario de Ciencias Exactas e Ingenierías, Universidad de Guadalajara, Guadalajara, JAL, Mexico; Macías-Islas, M.Á., Departamento de Neurología, Hospital de Especialidades Del Centro Médico Nacional de Occidente, Instituto Mexicano Del Seguro Social, Guadalajara, JAL, Mexico; Alatorre Jiménez, M.A., Laboratorio de Desarrollo-Envejecimiento: Enfermedades Neurodegenerativas, División de Neurociencias, Instituto Mexicano Del Seguro Social, Sierra Mojada No. 800, Colonia-Independencia 44340 Guadalajara, JAL, Mexico; González-Renovato, E.D., Laboratorio de Desarrollo-Envejecimiento: Enfermedades Neurodegenerativas, División de Neurociencias, Instituto Mexicano Del Seguro Social, Sierra Mojada No. 800, Colonia-Independencia 44340 Guadalajara, JAL, Mexico; Cortés-Enríquez, F., Laboratorio de Desarrollo-Envejecimiento: Enfermedades Neurodegenerativas, División de Neurociencias, Instituto Mexicano Del Seguro Social, Sierra Mojada No. 800, Colonia-Independencia 44340 Guadalajara, JAL, Mexico; Célis De La Rosa, A., Departamento de Salud Pública, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, JAL, Mexico; Velázquez-Brizuela, I.E., Laboratorio de Desarrollo-Envejecimiento: Enfermedades Neurodegenerativas, División de Neurociencias, Instituto Mexicano Del Seguro Social, Sierra Mojada No. 800, Colonia-Independencia 44340 Guadalajara, JAL, Mexico; Ortiz, G.G., Laboratorio de Desarrollo-Envejecimiento: Enfermedades Neurodegenerativas, División de Neurociencias, Instituto Mexicano Del Seguro Social, Sierra Mojada No. 800, Colonia-Independencia 44340 Guadalajara, JAL, Mexico
dc.relation.isReferencedByScopus
dc.relation.isReferencedByMEDLINE
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dc.identifier.urlhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=24701363
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