Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/66004
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dc.contributor.authorRamirez-De Los Santos, S.
dc.contributor.authorSanchez-Hernandez, P.E.
dc.contributor.authorMunoz-Valle, J.F.
dc.contributor.authorPalafox-Sanchez, C.A.
dc.contributor.authorRosales-Rivera, L.Y.
dc.contributor.authorGarcia-Iglesias, T.
dc.contributor.authorDaneri-Navarro, Adrián
dc.contributor.authorRamirez-Duenas, M.G.
dc.date.accessioned2015-11-19T18:50:55Z-
dc.date.available2015-11-19T18:50:55Z-
dc.date.issued2012
dc.identifier.urihttp://hdl.handle.net/20.500.12104/66004-
dc.description.abstractObjective: Rheumatoid Arthritis (RA) is an autoimmune and chronic inflammatory disease of unknown etiology. Killer cell immunoglobulin-like receptors are expressed on the surface of natural killer cells and CD28null T-cells, both present in synovial membrane of RA. Therefore we evaluated the associations of KIR genes with RA. Methods: 16 KIR genes were genotyped in 100 healthy subjects (HS) and 100 RA patients from Western Mexico using PCR-SSP. Differences in KIR genotypes and gene frequencies were assessed using the X 2 test. Results: Gene frequency of KIR2DL3 was lower in RA than in HS (p= 0.0019), whereas KIR2DL2 and KIR2DS2 were higher in RA than HS (p =0.0004 and p = 0.0487, respectively). In addition were identified 38 genotypes (from G1-G38) in both studied groups, and the genotype frequencies of G1, G6 and G14 showed significant differences (p =0.0001, p =0.0208 and p =0.0300, respectively). Conclusions: The presence of KIR2DL2, KIR2DS2 and absence of KIR2DL3 are associated with RA. Moreover, two genotypes BX are associated with RA. These results suggest that KIRs can be involved in RA susceptibility. © 2012-IOS Press and the authors. All rights reserved.
dc.titleAssociations of killer cell immunoglobulin-like receptor genes with rheumatoid arthritis
dc.typeArticle
dc.identifier.doi10.3233/DMA-2012-0927
dc.relation.ispartofjournalDisease Markers
dc.relation.ispartofvolume33
dc.relation.ispartofissue4
dc.relation.ispartofpage201
dc.relation.ispartofpage206
dc.subject.keywordautoimmune disease; CD158; killer cell immunoglobulin-like receptor; KIR; natural killer cell receptors; rheumatoid arthritis
dc.contributor.affiliationRamírez-De Los Santos, S., Laboratorio de Inmunología, Departamento de Fisiología, Universidad de Guadalajara, Calle Sierra Mojada No. 950, Colonia Independencia, Guadalajara, Jalisco, C.P. 44340, Mexico, Departamento de Fisiología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; Sánchez-Hernández, P.E., Laboratorio de Inmunología, Departamento de Fisiología, Universidad de Guadalajara, Calle Sierra Mojada No. 950, Colonia Independencia, Guadalajara, Jalisco, C.P. 44340, Mexico; Muñoz-Valle, J.F., Departamento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; Palafox-Sánchez, C.A., Departamento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; Rosales-Rivera, L.Y., Laboratorio de Inmunología, Departamento de Fisiología, Universidad de Guadalajara, Calle Sierra Mojada No. 950, Colonia Independencia, Guadalajara, Jalisco, C.P. 44340, Mexico, Departamento de Fisiología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; García-Iglesias, T., Laboratorio de Inmunología, Departamento de Fisiología, Universidad de Guadalajara, Calle Sierra Mojada No. 950, Colonia Independencia, Guadalajara, Jalisco, C.P. 44340, Mexico; Daneri-Navarro, A., Laboratorio de Inmunología, Departamento de Fisiología, Universidad de Guadalajara, Calle Sierra Mojada No. 950, Colonia Independencia, Guadalajara, Jalisco, C.P. 44340, Mexico; Ramírez-Dueñas, M.G., Laboratorio de Inmunología, Departamento de Fisiología, Universidad de Guadalajara, Calle Sierra Mojada No. 950, Colonia Independencia, Guadalajara, Jalisco, C.P. 44340, Mexico
dc.contributor.affiliationDaneri-Navarro, Adrián., Universidad de Guadalajara. Centro Universitario de Ciencias de la Salud
dc.subject.headingIndex Medicus;Adolescent;Adult;Aged;Aged, 80 and over;Arthritis, Rheumatoid/di [Diagnosis];Arthritis, Rheumatoid/ge [Genetics];Case-Control Studies;Female;Gene Frequency;Genetic Association Studies;Genotype;Humans;Male;Mexico;Middle Aged;Receptors, KIR/ge [Genetics];Receptors, KIR/me [Metabolism];Receptors, KIR2DL2/ge [Genetics];Receptors, KIR2DL2/me [Metabolism];Receptors, KIR2DL3/ge [Genetics];Receptors, KIR2DL3/me [Metabolism];Transcription, Genetic
dc.relation.isReferencedByScopus
dc.relation.isReferencedByWOS
dc.relation.isReferencedByMEDLINE
dc.identifier.urlhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84872235735&partnerID=40&md5=fee343919fda7e7c5585035482fb3220
dc.identifier.urlhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=22960345
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