Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/66001
Title: Macrophage migration inhibitory factor: Association of -794 CATT5-8 and -173 G>C polymorphisms with TNF-α in systemic lupus erythematosus
Author: De la Cruz-Mosso, U.
Bucala, R.
Palafox-Sanchez, C.A.
Parra-Rojas, I.
Padilla-Gutierrez, J.R.
Pereira-Suarez, A.L.
Rangel-Villalobos, H.
Vazquez-Villamar, M.
Angel-Chavez, L.I.
Munoz-Valle, J.F.
Issue Date: 2014
Abstract: Macrophage migration inhibitory factor (MIF) is an upstream immunoregulatory cytokine associated with the pathogenesis of autoimmune inflammatory diseases. There is evidence that MIF functions in a positive feedback loop with TNF-α that could perpetuate the inflammatory process in systemic lupus erythematosus (SLE). In this case-control study we investigated whether commonly occurring functional MIF polymorphisms are associated with SLE as well as with MIF and TNF-α serum levels in a Mexican-Mestizo population. Genotyping of the -794 CATT5-8 (rs5844572) and -173 G>C (rs755622) MIF polymorphisms was performed by PCR and PCR-RFLP, respectively in 186 SLE patients and 200 healthy subjects. MIF and TNF-α serum levels were determined by ELISA. A significant increase of MIF and TNF-α levels was found in SLE patients. According to a genetic model, we found a significant association of genotypes carrying the -794 CATT7 and -173*C risk alleles with susceptibility to SLE and with a significant increase of TNF-α. In conclusion, MIF gene polymorphisms are associated with SLE susceptibility and with an increase of TNF-α serum levels in a Mexican-Mestizo population. © 2014 American Society for Histocompatibility and Immunogenetics.
URI: http://hdl.handle.net/20.500.12104/66001
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