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Title: Isosorbide dinitrate spray as therapeutic strategy for treatment of chronic venous ulcers
Author: Sanchez-Vazquez, R.
Briseno-Rodriguez, G.
Cardona-Munoz, E.G.
Galvez-Gastelum, F.J.
Totsuka-Sutto, S.E.
Garcia-Benavides, L.
Issue Date: 2008
Abstract: Venous ulcers are the most common form of leg ulcers, which induce lesion because of the loss of substances deposited on the damaged skin. Isosorbide dinitrate is a vasodilator with effects on both arteries and veins and induces opening of vascular layers. The objective is to study the effects of isosorbide dinitrate-spray in patients with chronic venous ulcers. Forty-five patients of both sexes with chronic venous ulcers were randomized to receive isosorbide dinitrate or placebo sprays daily for 3 months. The ulcers were measured and clinical characteristics were taken every 15 days during the treatment. Patients treated with isosorbide dinitrate showed an improvement of the ulcerated area (71.29%) compared with patients treated with placebo (54.35%). The histopathological study indicated an increment in the number of hypertrophic and hyperplasic capillaries. Macroscopically, the isosorbide dinitrate-treatment showed the best results, but it was only during the first 6 weeks of treatment. Patients with chronic venous ulcer receiving isosorbide dinitrate spray showed improvement. © 2008 Sage Publications.
Appears in Collections:Producción científica UdeG (prueba)

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