Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/65475
Title: Implications in the difference of anti-Mi-2 and -p155/140 autoantibody prevalence in two dermatomyositis cohorts from Mexico City and Guadalajara
Author: Petri, M.H.
Satoh, M.
Martin-Marquez, B.T.
Vargas-Ramirez, R.
Jara, L.J.
Saavedra, M.A.
Cruz-Gonzalez, C.
Andrade-Ortega, L.
Vera-Lastra, O.
Salazar-Paramo, M.
Prieto-Parra, R.E.
Gonzalez-Lopez, L.
Gamez-Nava, J.I.
Ramirez-Sanchez, H.U.
Chan, J.Y.F.
Ross, S.J.
Chan, E.K.L.
Vazquez-Del Mercado, M.
Issue Date: 2013
Abstract: Introduction: Autoantibodies and clinical manifestations in polymyositis/dermatomyositis (PM/DM) are affected by both genetic and environmental factors. The high prevalence of DM and anti-Mi-2 in Central America is thought to be associated with the high UV index of the area. The prevalences of autoantibodies and the clinical manifestations of PM/DM were evaluated comparing two cohorts in Mexico. Methods: Ninety-five Mexican patients with PM/DM (66 DM, 29 PM; 67 Mexico City, 28 Guadalajara) were studied. Autoantibodies were characterized by immunoprecipitation using 35S-methionine labeled K562 cell extract. Clinical information was obtained from medical records. Results: DM represented 69% of PM/DM and anti-Mi-2 was the most common autoantibody (35%), followed by anti-p155/140 (11%); however, anti-Jo-1 was only 4%. The autoantibody profile in adult-onset DM in Mexico City versus Guadalajara showed striking differences: anti-Mi-2 was 59% versus 12% (P = 0.0012) whereas anti-p155/140 was 9% versus 35% (P = 0.02), respectively. A strong association of anti-Mi-2 with DM was confirmed and when clinical features of anti-Mi-2 (+) DM (n = 30) versus anti-Mi-2 (-) DM (n = 36) were compared, the shawl sign (86% versus 64%, P < 0.05) was more common in the anti-Mi-2 (+) group (P = 0.0001). Levels of creatine phosphokinase (CPK) were higher in those who were anti-Mi-2 (+) but they responded well to therapy. Conclusions: Anti-Mi-2 has a high prevalence in Mexican DM and is associated with the shawl sign and high CPK. The prevalence of anti-Mi-2 and anti-p155/140 was significantly different in Mexico City versus Guadalajara, which have a similar UV index. This suggests roles of factors other than UV in anti-Mi-2 antibody production. © 2013 Petri et al.; licensee BioMed Central Ltd.
URI: http://hdl.handle.net/20.500.12104/65475
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