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Title: IL-17 Increased in the Third Trimester in Healthy Women with Term Labor
Author: Martinez-Garcia, E.A.
Chavez-Robles, B.
Sanchez-Hernandez, P.E.
Nunez-Atahualpa, L.
Martin-Maquez, B.T.
Munoz-Gomez, A.
Gonzalez-Lopez, L.
Gamez-Nava, J.I.
Salazar-Paramo, M.
Davalos-Rodriguez, I.
Petri, M.H.
Zuniga-Tamayo, D.
Vargas-Ramirez, R.
Vazquez-Del Mercado, M.
Issue Date: 2011
Abstract: Citation Martínez-García EA, Chávez-Robles B, Sánchez-Hernández PE, Nuñez-Atahualpa L, Martín-Máquez BT, Muñoz-Gómez A, González-López L, Gámez-Nava JI, Salazar-Páramo M, Dávalos-Rodríguez I, Petri MH, Zuñiga-Tamayo D, Vargas-Ramírez R, Vázquez-Del Mercado M. IL-17 Increased in the third trimester in healthy women with term labor. Am J Reprod Immunol 2011; 65: 99-103Introduction The function, peripheral blood expression, and physiologic importance of IL-17 is not well established. Detection of IL-17 in sera and plasma samples from patients with pre-eclampsia has been reported with inconsistent results. To establish the l levels of the IL-17 at peripheral level, we studied prospectively a cohort of 13 healthy pregnant women.Objective To evaluate the changes in serum levels of IL-17 in healthy pregnant women in a prospective cohort.Material and Methods Thirteen healthy pregnant women were prospectively followed to evaluate serum levels of IL-17. Each patient was evaluated at each trimester. IL-17 levels were measured by ELISA. The statistical analysis was done using repeated measures anova and Bonferroni's multiple comparison test.Results IL-17 levels were significantly increased from first trimester with a mean of 14.61 up to 31.78 pg/mL at third trimester (P < 0.05), but when detectable, they were almost identical range in all trimesters.Conclusions We propose that IL-17 levels in healthy women are present with very similar range levels during the whole pregnancy but the average is increased during the third trimester maybe as a part of the complex network of cytokines as a result of implantation, fetal development, and labor process itself. © 2010 John Wiley & Sons A/S.
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