Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/65243
Title: Hepatitis C virus infection and type 2 diabetes mellitus in Mexican patients.
Author: Chiquete, E.
Ochoa-Guzman, A.
Garcia-Lamas, L.
Anaya-Gomez, F.
Gutierrez-Manjarrez, J.I.
Sanchez-Orozco, L.V.
Godinez-Gutierrez, S.A.
Maldonado, M.
Roman, S.
Panduro-Cerda, Arturo
Issue Date: 2012
Abstract: to measure the frequency of type 2 diabetes mellitus (T2DM) in patients with confirmed HCV infection. we studied 125 adults reactive to anti-HCV antibodies (62.4 % women, mean age 46.8 years) who received confirmatory RT-PCR testing for viremia (63.2 % HCV-RNA-positive). twenty-two patients had T2DM (17.6 %, 95 % confidence interval: 11.8-25.3 %; mean National prevalence: 14.4 %), more frequent among patients with detectable viremia than in negative cases (23.3 % vs. 9.6 %, respectively; p = 0.04), and among those with advanced liver disease, than in compensated patients (28.9 % vs. 11.3 %, respectively; p = 0.01). Fourteen (17.7 %) patients received interferon-based treatment and 6 (42.8 %) had sustained virology response. None of the 6 responders had T2DM, but 2 of the 8 (25 %) non-responders had diabetes. T2DM patients were older than those without diabetes (57.7 vs. 44.5 years, p < 0.001), and after multivariate analysis, only age was significantly associated with diagnosis of T2DM. T2DM was highly prevalent among patients with chronic HCV infection. Age was the most important determining factor.
URI: http://hdl.handle.net/20.500.12104/65243
Appears in Collections:Producción científica UdeG (prueba)

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