Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/65105
Title: Genotypes and S-gene variability of Mexican hepatitis B virus strains
Author: Sanchez, L.V.
Maldonado, M.
Bastidas-Ramirez, B.E.
Norder, H.
Panduro-Cerda, Arturo
Issue Date: 2002
Abstract: The genotypes and subtypes of 15 Mexican hepatitis B virus strains were determined by sequencing and phylogenetic analysis of the small S-gene. The most predominant strains were found to be divergent genotype/subtype F/adw4 strains (66.6%), followed by A/adw2 (20.0%), D/ayw3 (6.7%), and G/adw2 (6.7%). The S-genes of the Mexican genotype F strains and two Nicaraguan strains described previously formed a subcluster with more than 4% divergence from the other strains within this genotype. The Mexican strains within genotypes A and D showed the highest homology with strains from Europe and the United States. Ten amino acid substitutions not described previously were found in the S-genes of strains from nine chronic carriers, whereas the S gene in strains from six acute hepatitis B patients were highly conserved as compared to their respective genotypes. One genotype F strain from an HBsAg positive chronic carrier had a T to A mutation at position 647, forming a translational stop at codon 216. Two genotype F strains from HBsAg negative chronic carriers had a Val180 instead of an Ala found in the other genotype F strains. This study shows that a divergent genotype F predominates in Mexican strains analyzed, which presented amino acid substitutions not reported previously outside the a determinant. © 2002 Wiley-Liss, Inc.
URI: http://hdl.handle.net/20.500.12104/65105
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