Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/64787
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dc.contributor.authorLoredo-Pozos, G.
dc.contributor.authorChiquete, E.
dc.contributor.authorOceguera-Villanueva, A.
dc.contributor.authorPanduro-Cerda, Arturo
dc.contributor.authorSiller-Lopez, F.
dc.contributor.authorRamos-Marquez, M.E.
dc.date.accessioned2015-11-19T18:49:45Z-
dc.date.available2015-11-19T18:49:45Z-
dc.date.issued2009
dc.identifier.urihttp://hdl.handle.net/20.500.12104/64787-
dc.description.abstractLow BRCA1 gene expression is associated with increased invasiveness and influences the response of breast carcinoma (BC) to chemotherapeutics. However, expression of BRCA1 and BRCA2 genes has not been completely characterized in premenopausal BC. We analyzed the clinical and immunohistochemical correlates of BRCA1 and BRCA2 expression in young BC women. We studied 62 women (mean age 38.8 years) who developed BC before the age of 45 years. BRCA1 and BRCA2 mRNA expression was assessed by reverse transcriptase-polymerase chain reaction (RT-PCR) and that of HER-2 and p53 proteins by immunohistochemistry. Body mass index (BMI) ≥27 (52%) and a declared family history of BC (26%) were the main risk factors. Ductal infiltrative adenocarcinoma was found in 86% of the cases (tumor size >5 cm in 48%). Disease stages I-IV occurred in 2, 40, 55, and 3%, respectively (73% implicating lymph nodes). Women aged ≥35 years (24%) had more family history of cervical cancer, stage III/IV disease, HER-2 positivity, and lower BRCA1 expression than older women (P < 0.05). BRCA1 and BRCA2 expression correlated in healthy, but not in tumor tissues (TT). Neither BRCA1 nor BRCA2 expression was associated with tumor histology, differentiation, nodal metastasis or p53 and HER-2 expression. After multivariate analysis, only disease stage explained BRCA1 mRNA levels in the lowest quartile. Premenopausal BC has aggressive clinical and molecular characteristics. Low BRCA1 mRNA expression is associated mainly with younger ages and advanced clinical stage of premenopausal BC. BRCA2 expression is not associated with disease severity in young BC women. © 2008 Humana Press Inc.
dc.titleExpression profile of BRCA1 and BRCA2 genes in premenopausal Mexican women with breast cancer: Clinical and immunohistochemical correlates
dc.typeArticle
dc.identifier.doi10.1007/s12032-008-9114-7
dc.relation.ispartofjournalMedical Oncology
dc.relation.ispartofvolume26
dc.relation.ispartofissue3
dc.relation.ispartofpage269
dc.relation.ispartofpage275
dc.subject.keywordBRCA1; BRCA2; Breast carcinoma; Gene expression; Mexico; mRNA
dc.contributor.affiliationLoredo-Pozos, G., Instituto de Enfermedades Crónico-Degenerativas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada 950. Colonia Independencia, Guadalajara, Jalisco C.P. 44340, Mexico; Chiquete, E., Departamento de Medicina Interna, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Mexico; Oceguera-Villanueva, A., Instituto Jaliciense de Cancerología, Guadalajara, Mexico; Panduro, A., Departamento de Biología Molecular, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Mexico; Siller-López, F., Instituto de Enfermedades Crónico-Degenerativas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada 950. Colonia Independencia, Guadalajara, Jalisco C.P. 44340, Mexico; Ramos-Márquez, M.E., Instituto de Enfermedades Crónico-Degenerativas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada 950. Colonia Independencia, Guadalajara, Jalisco C.P. 44340, Mexico
dc.contributor.affiliationPanduro-Cerda, Arturo., Universidad de Guadalajara
dc.subject.headingIndex Medicus;Adult;Apoptosis Regulatory Proteins;BRCA1 Protein/bi [Biosynthesis];BRCA1 Protein/ge [Genetics];BRCA2 Protein/bi [Biosynthesis];BRCA2 Protein/ge [Genetics];Breast Neoplasms/ge [Genetics];Breast Neoplasms/me [Metabolism];Breast Neoplasms/pa [Pathology];Chi-Square Distribution;Female;Gene Expression Profiling;Humans;Immunohistochemistry;Logistic Models;Mexico;Premenopause/ge [Genetics];Premenopause/me [Metabolism];Risk Factors;Young Adult
dc.relation.isReferencedByScopus
dc.relation.isReferencedByMEDLINE
dc.relation.isReferencedByWOS
dc.identifier.urlhttp://www.scopus.com/inward/record.url?eid=2-s2.0-77954086867&partnerID=40&md5=68a42fdc0ca8672d78549b60083b2204
dc.identifier.urlhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med5&AN=19012002
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