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Title: Effects of melatonin on plasma levels of TNF-α, IL-1 and IL-6 in mice after lipopolysaccharide administration
Author: Bitzer-Quintero, O.K.
Ortiz, G.G.
Ruiz-Rizo, L.
Torres-Mendoza, B.M.
Vazquez-Valls, E.
Rodriguez-Perez, M.
Issue Date: 2005
Abstract: Bidirectional dependence exists between the immune and neuroendocrine systems, with common chemical messengers, such as melatonin (MLT), having immunoregulatory functions in some mechanisms of endotoxic shock. We used 10-12-week-old female Balb/c mice, with an average weight of 22-24 g, maintained under a 12 h light-dark cycle. The LD100 of lipopolysaccharide (LPS) was determined to be 10 mg/kg (ip.) from a dose-response curve. Pretreatment with MLT (10 mg/kg ip.) increased survival by 60%, decreased plasma TNF-αε and increased IL-1. No significant changes were observed in levels of plasma IL-6. © 2005 Taylor & Francis Group Ltd.
Appears in Collections:Producción científica UdeG (prueba)

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