Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/64317
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dc.contributor.authorIbanez-Hernandez, M.G.
dc.contributor.authorMacias-Islas, M.A.
dc.contributor.authorZavalza-Gomez, A.B.
dc.contributor.authorPacheco-Moises, F.P.
dc.contributor.authorOrtiz, G.G.
dc.date.accessioned2015-11-19T18:49:16Z-
dc.date.available2015-11-19T18:49:16Z-
dc.date.issued2008
dc.identifier.urihttp://hdl.handle.net/20.500.12104/64317-
dc.description.abstractBackground: There is controversy about the prevention of Alzheimer's disease with nonsteroidal antiinflammatory drugs (NSAIDs). Our objective was to evaluate the effect of ibuprofen and acetylsalicylic acid on cognitive impairment, serum total antioxidant power (TAP) and isoprostane (8-iso-PGF2á). Methods: We applied from April 2004 to February 2006 a Folstein mini-mental state (MMSE), Syndrome Kurtz Test (SKT) and a geriatric depression scale (Yasevage) to eighteen eligible women. They were 55 years and older. All women (n=18) with normal cognitive state were randomized to ibuprofen 400 mg per day (n=9) and acetylsalicylic acid 500 mg per day (n=9) for one year. Serum TAP and 8-iso-PGF2á were performed at baseline, after six months and one year of treatment. Results: After one year of treatment with acetylsalicylic acid five women (55.6%) raised their score 4 points in MMSE compared with 3 points increased (33.3%) showed by the ibuprofen group. TAP increased (p=0.01) and 8-iso-PGF2á reduced (p=0.01) in both groups compared with baseline. Conclusions: Both drugs improved the cognitive state and oxidative status of our population.
dc.titleEffect of ibuprofen and acetylsalicylic acid on cognitive decline, total antioxidant power and serum isoprostanes [Efecto del ibuprofeno y ácido acetilsalicílico sobre el deterioro cognitivo, poder antioxidante total e isoprostanos séricos]
dc.typeArticle
dc.relation.ispartofjournalGaceta Medica de Mexico
dc.relation.ispartofvolume144
dc.relation.ispartofissue6
dc.relation.ispartofpage497
dc.relation.ispartofpage502
dc.subject.keywordAcetylsalicylic acid; Cognitive impairment; Ibuprofen; Isoprostane; Serum total antioxidant power
dc.contributor.affiliationIbáñez-Hernández, M.G., Clínica de Demencias, Hospital de Especialidades, Centro Médico Nacional de Occidente, IMSS, Guadalajara, Jalisco, Mexico; Macías-Islas, M.A., Clínica de Demencias, Hospital de Especialidades, Centro Médico Nacional de Occidente, IMSS, Guadalajara, Jalisco, Mexico; Zavalza-Gómez, A.B., Unidad Médica de Alta Especialidad, Hospital de Gineco-Obstetricia, Centro Médico Nacional de Occidente, IMSS, Guadalajara, Jalisco, Mexico; Pacheco-Moisés, F.P., Departamento de Química, Centro Universitario de Ciencias Exactas e Ingenierías, Universidad de Guadalajara, Jalisco, Mexico; Ortiz, G.G., Departamento de Química, Centro Universitario de Ciencias Exactas e Ingenierías, Universidad de Guadalajara, Jalisco, Mexico
dc.relation.isReferencedByScopus
dc.identifier.urlhttp://www.scopus.com/inward/record.url?eid=2-s2.0-61549092177&partnerID=40&md5=e8ee132a184e03771c6af6dabfaae566
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