Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/64267
Title: Effect of a symbiotic gel (Lactobacillus acidophilus + Bifidobacterium lactis + Inulin) on presence and severity of gastrointestinal symptoms in hemodialysis patients
Author: Viramontes-Horner, D.
Marquez-Sandoval, F.
Martin-del-Campo, F.
Vizmanos-Lamotte, B.
Sandoval-Rodriguez, A.
Armendariz-Borunda, J.
Garcia-Bejarano, H.
Renoirte-Lopez, K.
Garcia-Garcia, G.
Issue Date: 2015
Abstract: Objective: The study aimed to assess the effect of a symbiotic gel on presence and severity of gastrointestinal symptoms (GIS) in hemodialysis patients. Design: A double-blinded, placebo-controlled, randomized, clinical trial was designed. The study was conducted at 2 public hospitals in Guadalajara, Mexico. Subjects and Intervention: Twenty-two patients were randomized to the intervention group (nutritional counseling+symbiotic gel) and 20 patients were randomized to the control group (nutritional counseling+placebo), during 2months of follow-up. Main Outcome Measure: Presence and monthly episodes of GIS were assessed by direct interview and severity by using the self-administered GIS questionnaire. Additionally, biochemical parameters, inflammatory markers, and nutritional status (dietary intake, subjective global assessment, anthropometry, and body composition) were evaluated. Results: After a 2-month treatment, intervention group had a significant reduction in prevalence and monthly episodes of vomit, heartburn, and stomachache, as well as a significant decrease in GIS severity compared with control group. Moreover, intervention group had a greater yet not significant decrease in the prevalence of malnutrition and a trend to reduce their C-reactive protein and tumor necrosis factor α levels compared with control group. No symbiotic-related adverse side effects were shown in these patients. Clinical studies with longer follow-up and sample size are needed to confirm these results. Conclusions: We concluded that administration of a symbiotic gel is a safe and simple way to improve common GIS in dialysis patients. © 2015 National Kidney Foundation, Inc.
URI: http://hdl.handle.net/20.500.12104/64267
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