Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/64150
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dc.contributor.authorTorres-Sanchez, E.D.
dc.contributor.authorGonzalez-Renovate, E.D.
dc.contributor.authorPacheco-Moises, F.P.
dc.contributor.authorRomero-Davalos, R.
dc.contributor.authorRomero-Tirado, L.A.
dc.contributor.authorHernandez-Andalon, J.J.
dc.contributor.authorVelazquez-Brizuela, I.E.
dc.contributor.authorCruz-Ramos, J.A.
dc.contributor.authorOrtiz, G.G.
dc.date.accessioned2015-11-19T18:49:05Z-
dc.date.available2015-11-19T18:49:05Z-
dc.date.issued2013
dc.identifier.urihttp://hdl.handle.net/20.500.12104/64150-
dc.description.abstractSepsis is a systemic host response which implicates an inflammatory state due to a bacterial infection and involving1 multiple organ failure. In order to modulate this systemic reaction, liver plays a pivotal role due to its central contribution in metabolism and host defense mechanism. The process of sepsis as an inflammatory condition results in the production of free radicals, in some cases induced by lip op oly saccharide which conducts to oxidative damage and mitochondrial impairment; these alterations may contribute to the pathophysiology of septic shock. The use of antioxidants in the treatment of this pathology reduces mitochondrial damage and oxidative stress, therefore in this study, treatment with Nutrisim© a nutritive supplement used empirically in the treatment of several degenerative disorders was tested in biochemical parameters indicative of oxidative stress and mitochondrial ATPase activity in rat liver mitochondria damage-induced by LPS. The results showed that treatment with Nutrisim© 30 min prior or after the LPS challenge significantly attenuates the end-products of lipid oxidation (p<0.05), restores total antioxidant capacity, the membrane fluidity and preserves ATPase activity. In conclusion, Nutrisim© administration prior or after LPS damage, ameliorates liver damage. Therefore, the beneficial effects of Nutrisim© against oxidative stress and ATPase activity in rat liver mitochondria presented in this study may suggest a potential chemoprotective effect in sepsis prevention. © 2013 Academic Journals Inc.
dc.titleBeneficial effect of nutrisim© against LPS-induced liver injury: Oxidative stress markers and mitochondrial ATP-ase activity
dc.typeArticle
dc.identifier.doi10.3923/ijbc.2013.38.46
dc.relation.ispartofjournalInternational Journal of Biological Chemistry
dc.relation.ispartofvolume7
dc.relation.ispartofissue1
dc.relation.ispartofpage38
dc.relation.ispartofpage46
dc.subject.keywordAtpase; Lipoperoxidation; Membrane fluidity; Mitochondria; Nutrisim©; Oxidative stress; sepsis
dc.contributor.affiliationTorres-Sanchez, E.D., Lab. de Mitocondria, Estres Oxidativo y Patologia, Division de Neurociencias. Centro de Investigacion Biomedica de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, Mexico; Gonzalez-Renovate, E.D., Lab. de Mitocondria, Estres Oxidativo y Patologia, Division de Neurociencias. Centro de Investigacion Biomedica de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, Mexico, Departamento de Quimica, Centro Universitario de Ciencias Exactas e Ingenierias, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; Pacheco-Moises, F.P., Departamento de Quimica, Centro Universitario de Ciencias Exactas e Ingenierias, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; Romero-Davalos, R., Lab. BioSim, Area de Desarrollo e Investigacion Cientifica, Mexico D.F., Mexico; Romero-Tirado, L.A., Lab. BioSim, Area de Desarrollo e Investigacion Cientifica, Mexico D.F., Mexico; Hernandez-Andalon, J.J., Lab. BioSim, Area de Desarrollo e Investigacion Cientifica, Mexico D.F., Mexico; Velazquez-Brizuela, I.E., OPD Instituto Jalisciense de Cancerologia, SSA-Jalisco, Guadalajara, Jalisco, Mexico; Cruz-Ramos, J.A., Lab. de Mitocondria, Estres Oxidativo y Patologia, Division de Neurociencias. Centro de Investigacion Biomedica de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, Mexico; Ortiz, G.G., Lab. de Mitocondria, Estres Oxidativo y Patologia, Division de Neurociencias. Centro de Investigacion Biomedica de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, Mexico
dc.relation.isReferencedByScopus
dc.identifier.urlhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84878624330&partnerID=40&md5=6f13caef7a6579fc4044557076ce1215
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