Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/64126
Full metadata record
DC FieldValueLanguage
dc.contributor.authorNuno-Arana, I.
dc.contributor.authorSahagun-Nunez, V.R.
dc.contributor.authorMunoz-Valle, J.F.
dc.contributor.authorSandoval, L.
dc.contributor.authorPinto-Escalante, D.
dc.contributor.authorPaez-Riberos, L.A.
dc.contributor.authorLazalde, B.
dc.contributor.authorMaldonado-Gonzalez, M.
dc.contributor.authorRangel-Villalobos, H.
dc.date.accessioned2015-11-19T18:49:02Z-
dc.date.available2015-11-19T18:49:02Z-
dc.date.issued2012
dc.identifier.urihttp://hdl.handle.net/20.500.12104/64126-
dc.description.abstractObjectives: Some Single nucleotide polymorphisms (SNPs) of several candidate genes have been associated with low bone mineral density (BMD) and fracture risk. As the genetic variability of such SNPs in Hispanic and Native American populations is scarce, we analyzed the three SNPs that have been related with bone mass disorders (Sp1, A163G, and BsmI) located in the genes of Type I Collagen (COL1A1), Osteoprotegerin (OPG), and Vitamin D receptor (VDR) in Mexican Mestizos (people resulting from post-Columbian admixture) and five Amerindian populations. Methods: We genotyped these three SNPs by Polymerase chain reaction (PCR) and Restriction fragment length polymorphisms (RFLPs) in 523 individuals from five Mexican Amerindian groups (Nahua, Maya, Purépecha, Tarahumara, and Huichol) and 227 western Mestizos (Jalisco state). Results: The modal allele was the same in all the six populations for Sp1-COL1A1 (S > 77%), A163G-OPG (A > 80%), and BsmI-VDR (b > 62%). Genotype distribution was in Hardy-Weinberg equilibrium in all SNPs/populations, excepting Sp1-COL1A1 in the Purépecha group and BsmI-VDR in Mestizo. In terms of the presumably Sp1-COL1A1 risk allele to low BMD (allele "s"), the Purépecha group showed the highest allele (23%) and homozygous (14.5%) frequencies. If the role of this allele as a genetic predisposing factor to low BMD were confirmed, this would mean increased susceptibility of Purépechas with regard to Europeans (14.5 vs. 6.8%). Conclusions: This finding presumably could influence the genetic susceptibility to low BMD in Purépechas. For the SNPs, BsmI-VDR and A163G-OPG, relative homogeneity was observed among the Mexican populations analyzed here. © 2012 Wiley Periodicals, Inc.
dc.titleDistribution of three SNPs related to low bone mineral density in Amerindian groups and Mestizos from Mexico
dc.typeArticle
dc.identifier.doi10.1002/ajhb.22262
dc.relation.ispartofjournalAmerican Journal of Human Biology
dc.relation.ispartofvolume24
dc.relation.ispartofissue4
dc.relation.ispartofpage569
dc.relation.ispartofpage572
dc.contributor.affiliationNuño-Arana, I., Instituto de Investigación en Genética Molecular, Centro Universitario de la Ciénega, Universidad de Guadalajara (CUCiénega-UdeG), Ocotlán, Jalisco, Mexico; Sahagún-Núñez, V.R., Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara (CUCS-UdeG), Guadalajara, Jalisco, Mexico; Muñoz-Valle, J.F., Grupo de Inmunogenética Funcional, Departamento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara (CUCS-UdeG), Guadalajara, Jalisco, Mexico; Sandoval, L., División de Genética, Centro de Investigación Biomédica de Occidente (CIBO-IMSS), Guadalajara, Jalisco, Mexico; Pinto-Escalante, D., Laboratorio de Genética, Centro Universitario de los Lagos, Universidad de Guadalajara (CULagos-UdeG), Lagos de Moreno, Jalisco, Mexico; Páez-Riberos, L.A., Centro de Investigacioines Regionales Hideyo Noguchi, Universidad Autónoma de Yucatán (UADY), Mérida, Yucatán, Mexico; Lazalde, B., Unidad de Investigación Biomédica, IMSS, Durango, Mexico; Maldonado-González, M., Servicio de Biología Molecular en Medicina, Antiguo Hospital Civil de Guadalajara, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; Rangel-Villalobos, H., Instituto de Investigación en Genética Molecular, Centro Universitario de la Ciénega, Universidad de Guadalajara (CUCiénega-UdeG), Ocotlán, Jalisco, Mexico
dc.subject.headingIndex Medicus;Bone Density;Collagen Type I/ge [Genetics];Gene Frequency;Genetic Predisposition to Disease;Genotype;Humans;Indians, North American;Mexico;Osteoporosis/et [Etiology];Osteoporosis/ge [Genetics];Osteoprotegerin/ge [Genetics];Polymerase Chain Reaction;Polymorphism, Restriction Fragment Length;Polymorphism, Single Nucleotide;Receptors, Calcitriol/ge [Genetics]
dc.relation.isReferencedByScopus
dc.relation.isReferencedByMEDLINE
dc.relation.isReferencedByWOS
dc.identifier.urlhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84862137630&partnerID=40&md5=a54d21059110a586a9aea14294d82a82
dc.identifier.urlhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=22434650
Appears in Collections:Producción científica UdeG (prueba)

Files in This Item:
There are no files associated with this item.


Items in RIUdeG are protected by copyright, with all rights reserved, unless otherwise indicated.