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Title: Association between the -794 (CATT)5-8 MIF gene polymorphism and susceptibility to acute coronary syndrome in a western Mexican population
Author: Valdes-Alvarado, E.
Munoz-Valle, J.F.
Valle, Y.
Sandoval-Pinto, E.
Garcia-Gonzalez, I.J.
Valdez-Haro, A.
De La Cruz-Mosso, U.
Flores-Salinas, H.E.
Padilla-Gutierrez, J.R.
Issue Date: 2014
Abstract: The macrophage migration inhibitory factor (MIF) is related to the progression of atherosclerosis, which, in turn, is a key factor in the development of acute coronary syndrome (ACS). MIF has a CATT short tandem repeat (STR) at position -794 that might be involved in its expression rate. The aim of this study was to investigate the association between the -794 CATT5-8 MIF gene polymorphism and susceptibility to ACS in a western Mexican population. This research included 200 ACS patients classified according to the criteria of the American College of Cardiology (ACC) and 200 healthy subjects (HS). The -794 CATT5-8 MIF gene polymorphism was analyzed using a conventional polymerase chain reaction (PCR) technique. The 6 allele was the most frequent in both groups (ACS: 54% and HS: 57%). The most common genotypes in ACS patients and HS were 6/7 and 6/6, respectively, and a significant association was found between the 6/7 genotype and susceptibility to ACS (68% versus 47% in ACS and HS, resp., P=0.03). We conclude that the 6/7 genotype of the MIF -794 CATT5-8 polymorphism is associated with susceptibility to ACS in a western Mexican population. © 2014 Emmanuel Valdés-Alvarado,et al.
Appears in Collections:Producción científica UdeG (prueba)

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