Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/63333
Title: Anti-cyclic citrullinated peptide (Anti-CCP) and anti-mutated citrullinated vimentin (Anti-MCV) relation with extra-articular manifestations in rheumatoid arthritis
Author: Gonzalez-Lopez, L.
Rocha-Munoz, A.D.
Ponce-Guarneros, M.
Flores-Chavez, A.
Salazar-Paramo, M.
Nava, A.
Cardona-Munoz, E.G.
Fajardo-Robledo, N.S.
Zavaleta-Muniz, S.A.
Garcia-Cobian, T.
Gamez-Nava, J.I.
Issue Date: 2014
Abstract: We evaluated the association between anti-cyclic citrullinated peptide antibodies (anti-CCP) and anti-mutated citrullinated vimentin antibodies (anti-MCV) with the presence of extra-articular (ExRA) manifestations in 225 patients with rheumatoid arthritis (RA). Ninety-five patients had ExRA and 130 had no ExRA. There was no association of anti-CCP and anti-MCV levels with the presence of ExRA as total group (P = 0.40 and P = 0.91, resp.). Making an analysis of individual manifestations, rheumatoid nodules were associated with positivity for rheumatoid factor (RF); (P = 0.01), anti-CCP (P = 0.048), and anti-MCV (P = 0.02). Instead, RF, anti-CCP, or anti-MCV were not associated with SS, chronic anemia, or peripheral neuropathy. Levels of anti-CCP correlated with the score of the Health Assessment Questionnaire-Disability Index (HAQ-Di) (r = 0.154, P = 0.03), erythrocyte sedimentation rate (ESR); (r = 0.155, P = 0.03), and RF (P = 0.254, P < 0.001), whereas anti-MCV titres only correlated with RF (r = 0.169, P = 0.02). On adjusted analysis, ExRA was associated with longer age (P = 0.015), longer disease duration (P = 0.007), higher DAS-28 score (P = 0.002), and higher HAQ-DI score (P = 0.007), but serum levels of anti-CCP and anti-MCV were not associated. These findings show the need to strengthen the evaluation of the pathogenic mechanisms implied in each specific ExRA manifestation. © 2014 Laura Gonzalez-Lopez et al.
URI: http://hdl.handle.net/20.500.12104/63333
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