Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/63321
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dc.contributor.authorSureda, F.X.
dc.contributor.authorJunyent, F.
dc.contributor.authorVerdaguer, E.
dc.contributor.authorAuladell, C.
dc.contributor.authorPelegri, C.
dc.contributor.authorVilaplana, J.
dc.contributor.authorFolch, J.
dc.contributor.authorCanudas, A.M.
dc.contributor.authorZarate, C.B.
dc.contributor.authorPallas, M.
dc.contributor.authorCamins, A.
dc.date.accessioned2015-11-18T23:43:46Z-
dc.date.available2015-11-18T23:43:46Z-
dc.date.issued2011
dc.identifier.urihttp://hdl.handle.net/20.500.12104/63321-
dc.description.abstractThe purpose of this review is to discuss potential pathways involved in the pathogenesis of neurodegenerative diseases, highlighting current pharmacological drug targets in neuronal apoptosis prevention. The incidence of these disorders is expected to rise in the coming years and so finding effective treatments represents a significant challenge for medicine. Alzheimer's disease and Parkinson's disease were both described almost a century ago and are the most important neurodegenerative disorders in the developed world. However, the molecular mechanisms that lead to the development of the neuronal pathology in both diseases are unclear. For this reason, despite substantial research in the area, an effective treatment for these diseases does not yet exist. In the present study we discuss in depth the pathways involved in apoptosis and neuronal death in neurodegenerative diseases. We also examine drugs that may have a neuroprotective effect. Inhibition of apoptosis mediated by oxidative stress generation and mitochondrial alteration or by the blockade of NMDA receptors could constitute a suitable therapeutic strategy for Alzheimer's disease. A multiple therapy with antioxidants, cell cycle inhibitors, GSK3β inhibitors, and STATINS could, in the future, represent a suitable strategy for delaying the progression of neurodegenerative diseases. This research contributes to the development of new methods in the field of apoptosis inhibitors that could provide the future tools for the treatment of Alzheimer's and Parkinson's disease, as well as other neurodegenerative diseases. © 2011 Bentham Science Publishers Ltd.
dc.titleAntiapoptotic drugs: A therapautic strategy for the prevention of neurodegenerative diseases
dc.typeReview
dc.identifier.doi10.2174/138161211795049732
dc.relation.ispartofjournalCurrent Pharmaceutical Design
dc.relation.ispartofvolume17
dc.relation.ispartofissue3
dc.relation.ispartofpage230
dc.relation.ispartofpage245
dc.subject.keywordAlzheimer's disease; Apoptosis; Cyclin-dependent kinases; Glutamate receptors; Neuronal cell death; Neuroprotective drugs. apoptosis; Parkinson's disease
dc.contributor.affiliationSureda, F.X., Unitat de Farmacología, Centros de Investigacion Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, C./ St. Llorenç 21, 43201 Reus (Tarragona), Spain; Junyent, F., Unitat de Farmacologia i Farmacognòsia Facultat de Farmàcia, Institut de Biomedicina (IBUB), Centros de Investigacion Biomedica en Red de Enfermedades Neuro., Universitat de Barcelona. Nucli Universitari de Pedralbes, 08028 Barcelona, Spain, Unitat de Bioquimica, Facultat de Medicina i Ciències de la Salut, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Universitat Rovira i Virgili, C./ St. Llorenç 21, 43201 Reus (Tarragona), Spain; Verdaguer, E., Departament de Biologia Cellular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain; Auladell, C., Departament de Biologia Cellular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain; Pelegri, C., Departament de Fisiologia, Centro de Investigación de Biomedicina en Red de Enfermedades Neurodegenerativas (CIBERNED), Universitat de Barcelona, Av. Joan XXIII s/n, 08028 Barcelona, Spain; Vilaplana, J., Departament de Fisiologia, Centro de Investigación de Biomedicina en Red de Enfermedades Neurodegenerativas (CIBERNED), Universitat de Barcelona, Av. Joan XXIII s/n, 08028 Barcelona, Spain; Folch, J., Unitat de Bioquimica, Facultat de Medicina i Ciències de la Salut, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Universitat Rovira i Virgili, C./ St. Llorenç 21, 43201 Reus (Tarragona), Spain; Canudas, A.M., Unitat de Farmacologia i Farmacognòsia Facultat de Farmàcia, Institut de Biomedicina (IBUB), Centros de Investigacion Biomedica en Red de Enfermedades Neuro., Universitat de Barcelona. Nucli Universitari de Pedralbes, 08028 Barcelona, Spain; Zarate, C.B., Departamento de Biología Celular y Molecular, CUCBA, Universidad de Guadalajara, Division de Neurociencias, Centro de Investigacion Biomedica de Occidente, Sierra Mojada 800, Col. Independencia, Guadalajara, Jalisco 44340, Mexico; Pallàs, M., Unitat de Farmacologia i Farmacognòsia Facultat de Farmàcia, Institut de Biomedicina (IBUB), Centros de Investigacion Biomedica en Red de Enfermedades Neuro., Universitat de Barcelona. Nucli Universitari de Pedralbes, 08028 Barcelona, Spain; Camins, A., Unitat de Farmacologia i Farmacognòsia Facultat de Farmàcia, Institut de Biomedicina (IBUB), Centros de Investigacion Biomedica en Red de Enfermedades Neuro., Universitat de Barcelona. Nucli Universitari de Pedralbes, 08028 Barcelona, Spain
dc.relation.isReferencedByScopus
dc.relation.isReferencedByWOS
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