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Title: A functional Ser413/Ser413 PAI-2 polymorphism is associated with susceptibility and damage index score in systemic lupus erythematosus
Author: Palafox-Senchez, C.A.
Vezquez-Del Mercado, M.
Orozco-Barocio, G.
Garcia-De La Torre, I.
Torres-Carrillo, N.
Torres-Carrillo, N.M.
Illades-Aguiar, B.
Munoz-Valle, J.F.
Issue Date: 2009
Abstract: Systemic lupus erythematosus in some cases is characterized for development of thrombotic events with a significantly increased risk of mortality. The frequencies and clinical associations of Ser413/Cys413 PAI-2 polymorphism in 40 systemic lupus erythematosus, 50 rheumatoid arthritis patients, and 100 healthy subjects were investigated. The Ser 413/Ser413 genotype frequency was 53% (lupus), 36% (rheumatoid arthritis), and 35% (healthy subjects). The Ser413 allele was associated with systemic lupus erythematosus (P =.04, odds ratio = 1.76, 95% confidence interval = 1.01-3.06). In all, 4 patient carriers of Ser 413/Ser413 genotype, developed thrombotic events. The lupus patients identified with Ser413/Ser413 genotype showed an increased damage (57%), compared with Ser413/Cys 413 and Cys413/Cys413 genotypes, with significant difference (P =.03). These findings suggest an association of Ser413 /Ser413 genotype with greater damage index score and Ser413 allele with systemic lupus erythematosus. Besides, PAI-2 polymorphism could be related with thrombotic phenomena in systemic lupus erythematosus.
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