Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/62777
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dc.contributor.authorVillafan-Bernal, J.R.
dc.contributor.authorLlamas-Covarrubias, M.A.
dc.contributor.authorMunoz-Valle, J.F.
dc.contributor.authorRivera-Leon, E.A.
dc.contributor.authorGonzalez-Hita, M.E.
dc.contributor.authorBastidas-Ramirez, B.E.
dc.contributor.authorGurrola-Diaz, C.M.
dc.contributor.authorArmendariz-Borunda, J.S.
dc.contributor.authorSanchez-Enriquez, S.
dc.date.accessioned2015-11-18T23:43:19Z-
dc.date.available2015-11-18T23:43:19Z-
dc.date.issued2014
dc.identifier.urihttp://hdl.handle.net/20.500.12104/62777-
dc.description.abstractBackground: The uncarboxylated osteocalcin (ucOC) has been described as a regulator of glucose metabolism in mice, and it is decreased in human type 2 diabetes mellitus (T2D). Although inversely correlated with serum glucose, insulin, and glycated hemoglobin, it is unclear if ucOC decrement is caused by diabetes or plays a role in the pathogen-esis and/or progression of the disease. Whatever the case may be, diabetes affects osteoblast gene expression, and possibly the proportion of ucOC over carboxylated OC (cOC). The association of ucOC/cOC index with glycemic status markers in patients with T2D has not been described before. Objective: The objective of this study was to assess the ucOC/cOC index and its relationship with glycemic status markers in patients with T2D. Methods: The ucOC/cOC index was determined by the quotient of ucOC and cOC serum levels in 80 T2D patients and 160 healthy subjects. The relationship between the ucOC/cOC index and glycemic status markers was evaluated. Results: The ucOC/cOC index was low and negatively correlated to fasting plasma glucose and homeostasis assessment-insulin resistance model in T2D patients. The odds ratio for T2D patients with an ucOC/cOC index below the cut-point obtained by receiver operating characteristic analysis was 12.64 (confidence interval, 5.75-27.77; P < 0.001). Conclusions: A value of ucOC/cOC index less than 0.3 is associated with markers of poor metabolic control in patients with T2D. Copyright © 2013 by The American Federation for Medical Research.
dc.titleA cut-point value of uncarboxylated to carboxylated index is associated with glycemic status markers in type 2 diabetes
dc.typeArticle
dc.identifier.doi10.231/JIM.0000000000000015
dc.relation.ispartofjournalJournal of Investigative Medicine
dc.relation.ispartofvolume62
dc.relation.ispartofissue1
dc.relation.ispartofpage33
dc.relation.ispartofpage36
dc.subject.keywordBone; Diabetes; Glucose; Insulin; Metabolism/General & Internal Medicine; Research & Experimental Medicine
dc.contributor.affiliationVillafán-Bernal, J.R., Cuerpo Académico UDG-CA-533 de Investigación en Bioquímica, Departamento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud, Sierra Mojada No. 950, Colonia Independencia, C.P. 44340 Guadalajara, Jalisco, Mexico; Llamas-Covarrubias, M.A., Servicio de VIH, Hospital Civil Fray Antonio Alcalde, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; Muñoz-Valle, J.F., Grupo de Inmunogenética Funcional, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; Rivera-León, E.A., Cuerpo Académico UDG-CA-533 de Investigación en Bioquímica, Departamento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud, Sierra Mojada No. 950, Colonia Independencia, C.P. 44340 Guadalajara, Jalisco, Mexico; González-Hita, M.E., Cuerpo Académico UDG-CA-533 de Investigación en Bioquímica, Departamento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud, Sierra Mojada No. 950, Colonia Independencia, C.P. 44340 Guadalajara, Jalisco, Mexico; Bastidas-Ramírez, B.E., Instituto de Enfermedades Crónico-Degenerativas, Departamento de Biología Molecular y Genómica, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; Gurrola-Díaz, C.M., Instituto de Enfermedades Crónico-Degenerativas, Departamento de Biología Molecular y Genómica, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; Armendáriz-Borunda, J.S., Instituto de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; Sánchez-Enríquez, S., Cuerpo Académico UDG-CA-533 de Investigación en Bioquímica, Departamento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud, Sierra Mojada No. 950, Colonia Independencia, C.P. 44340 Guadalajara, Jalisco, Mexico
dc.subject.headingIndex Medicus;Adult;Biological Markers/bl [Blood];Blood Glucose/me [Metabolism];Cohort Studies;Cross-Sectional Studies;Diabetes Mellitus, Type 2/bl [Blood];Diabetes Mellitus, Type 2/di [Diagnosis];Female;Glycemic Index/ph [Physiology];Humans;Male;Middle Aged;Osteocalcin/bl [Blood]
dc.relation.isReferencedByScopus
dc.relation.isReferencedByWOS
dc.relation.isReferencedByMEDLINE
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dc.identifier.urlhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=24113735
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