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Title: A cut-point value of uncarboxylated to carboxylated index is associated with glycemic status markers in type 2 diabetes
Author: Villafan-Bernal, J.R.
Llamas-Covarrubias, M.A.
Munoz-Valle, J.F.
Rivera-Leon, E.A.
Gonzalez-Hita, M.E.
Bastidas-Ramirez, B.E.
Gurrola-Diaz, C.M.
Armendariz-Borunda, J.S.
Sanchez-Enriquez, S.
Issue Date: 2014
Abstract: Background: The uncarboxylated osteocalcin (ucOC) has been described as a regulator of glucose metabolism in mice, and it is decreased in human type 2 diabetes mellitus (T2D). Although inversely correlated with serum glucose, insulin, and glycated hemoglobin, it is unclear if ucOC decrement is caused by diabetes or plays a role in the pathogen-esis and/or progression of the disease. Whatever the case may be, diabetes affects osteoblast gene expression, and possibly the proportion of ucOC over carboxylated OC (cOC). The association of ucOC/cOC index with glycemic status markers in patients with T2D has not been described before. Objective: The objective of this study was to assess the ucOC/cOC index and its relationship with glycemic status markers in patients with T2D. Methods: The ucOC/cOC index was determined by the quotient of ucOC and cOC serum levels in 80 T2D patients and 160 healthy subjects. The relationship between the ucOC/cOC index and glycemic status markers was evaluated. Results: The ucOC/cOC index was low and negatively correlated to fasting plasma glucose and homeostasis assessment-insulin resistance model in T2D patients. The odds ratio for T2D patients with an ucOC/cOC index below the cut-point obtained by receiver operating characteristic analysis was 12.64 (confidence interval, 5.75-27.77; P < 0.001). Conclusions: A value of ucOC/cOC index less than 0.3 is associated with markers of poor metabolic control in patients with T2D. Copyright © 2013 by The American Federation for Medical Research.
Appears in Collections:Producción científica UdeG (prueba)

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