Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/62769
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dc.contributor.authorArmendariz-Borunda, J.
dc.contributor.authorLyra-Gonzalez, I.
dc.contributor.authorMedina-Preciado, D.
dc.contributor.authorGonzalez-Garcia, I.
dc.contributor.authorMartinez-Fong, D.
dc.contributor.authorMiranda, R.A.
dc.contributor.authorMagana-Castro, R.
dc.contributor.authorPena-Santoyo, P.
dc.contributor.authorGarcia-Rocha, S.
dc.contributor.authorBautista, C.A.
dc.contributor.authorGodoy, J.
dc.contributor.authorFlores-Montana, J.
dc.contributor.authorFloresvillar-Mosqueda, J.
dc.contributor.authorArmendariz-Vazquez, O.
dc.contributor.authorLucano-Landeros, M.S.
dc.contributor.authorVazquez-Del Mercado, M.
dc.contributor.authorSanchez-Parada, M.G.
dc.date.accessioned2015-11-18T23:43:18Z-
dc.date.available2015-11-18T23:43:18Z-
dc.date.issued2012
dc.identifier.urihttp://hdl.handle.net/20.500.12104/62769-
dc.description.abstractBackground: Pathologic skin scarring reversion remains a big challenge for surgeons, as disfiguring scars have a dramatic influence on patient's quality of life. Methods: A controlled clinical trial was conducted to evaluate 8% pirfenidone (PFD) gel administered topically 3 times a day during 6 months to 33 pediatric patients with hypertrophic scars caused by burns. A total of 30 patients with hypertrophic scars with identical Vancouver Scar Scale values were treated with pressure therapy and included as controls. Improvements were evaluated by Vancouver Scar Scale and a Visual Analog Scale. Safety parameters were determined by the presence of adverse events and monitoring laboratory and hematology parameters. Results: Patients treated with PFD during 6 months presented a continuous monthly statistically significant scar regression in comparison with the initial Vancouver measurement (P = <0.001). PFD group showed a higher improvement of all scar features as compared with control group treated with pressure therapy (P = <0.001). In the PFD group, 9 of 33 patients (27%) had their scores decreased in Vancouver classification by more than 55%, 22 patients (67%) had a 30% to 45% decrease, whereas 2 patients (6%) had a 30% decrease or less. Control group treated with pressure therapy showed a slight improvement in 16% of cases on an average. Patients did not show serious adverse effects or laboratory alterations throughout the study. Conclusions: Topical administration of 8% PFD gel 3 times a day is more effective and safe in the treatment of hypertrophic scars caused by burns in children, as compared with standard pressure therapy. © 2012 by Lippincott Williams & Wilkins.
dc.titleA controlled clinical trial with pirfenidone in the treatment of pathological skin scarring caused by burns in pediatric patients
dc.typeArticle
dc.identifier.doi10.1097/SAP.0b013e31821b6d08
dc.relation.ispartofjournalAnnals of Plastic Surgery
dc.relation.ispartofvolume68
dc.relation.ispartofissue1
dc.relation.ispartofpage22
dc.relation.ispartofpage28
dc.subject.keywordburn scars; burns; pathological skin scarring; pediatric bur; Pirfenidone; scar; scar regression; Vancouver Scar Scale/Surgery
dc.contributor.affiliationArmendariz-Borunda, J., Department of Molecular Biology and Genomics, Institute for Molecular Biology in Medicine and Gene Therapy, University of Guadalajara, Guadalajara, Mexico, OPD, Hospital Civil de Guadalajara, Guadalajara, Mexico; Lyra-Gonzalez, I., Department of Molecular Biology and Genomics, Institute for Molecular Biology in Medicine and Gene Therapy, University of Guadalajara, Guadalajara, Mexico; Medina-Preciado, D., OPD, Hospital Civil de Guadalajara, Guadalajara, Mexico; Gonzalez-García, I., OPD, Hospital Civil de Guadalajara, Guadalajara, Mexico; Martinez-Fong, D., Department of Physiology, Biophysics and Neurosciences, CINVESTAV, Mexico D.F., Mexico; Miranda, R.A., OPD, Hospital Civil de Guadalajara, Guadalajara, Mexico; Magaña-Castro, R., Cell Therapy and Technology, S.A. de C.V., Mexico D.F., Mexico; Peña-Santoyo, P., Cell Therapy and Technology, S.A. de C.V., Mexico D.F., Mexico; Garcia-Rocha, S., OPD, Hospital Civil de Guadalajara, Guadalajara, Mexico; Bautista, C.A., OPD, Hospital Civil de Guadalajara, Guadalajara, Mexico; Godoy, J., OPD, Hospital Civil de Guadalajara, Guadalajara, Mexico; Flores-Montana, J., Faculty of Medicine, Autonomous University of Chihuahua, Chihuahua, Mexico; Floresvillar-Mosqueda, J., Department of Molecular Biology and Genomics, Institute for Molecular Biology in Medicine and Gene Therapy, University of Guadalajara, Guadalajara, Mexico; Armendariz-Vazquez, O., Department of Molecular Biology and Genomics, Institute for Molecular Biology in Medicine and Gene Therapy, University of Guadalajara, Guadalajara, Mexico; Lucano-Landeros, M.S., Department of Molecular Biology and Genomics, Institute for Molecular Biology in Medicine and Gene Therapy, University of Guadalajara, Guadalajara, Mexico; Vazquez-Del Mercado, M., Institute for Rheumatology and Muscle- Skeletal Research, CUCS, University of Guadalajara, Guadalajara, Mexico; Sanchez-Parada, M.G., Department of Molecular Biology and Genomics, Institute for Molecular Biology in Medicine and Gene Therapy, University of Guadalajara, Guadalajara, Mexico
dc.subject.headingIndex Medicus;Administration, Cutaneous;Adolescent;Anti-Inflammatory Agents, Non-Steroidal/tu [Therapeutic Use];Burns/co [Complications];Child;Child, Preschool;Cicatrix, Hypertrophic/dt [Drug Therapy];Cicatrix, Hypertrophic/et [Etiology];Cicatrix, Hypertrophic/th [Therapy];Compression Bandages;Drug Administration Schedule;Female;Gels;Humans;Male;Pilot Projects;Prospective Studies;Pyridones/tu [Therapeutic Use];Treatment Outcome
dc.relation.isReferencedByScopus
dc.relation.isReferencedByWOS
dc.relation.isReferencedByMEDLINE
dc.identifier.urlhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84855202918&partnerID=40&md5=0b8d6130153be90887e0a79704d83686
dc.identifier.urlhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=21659848
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