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|dc.contributor.author||de Diego JM|
|dc.contributor.author||de la Morena J|
|dc.description.abstract||The usefulness and clinical applicability of quantitative plasma polymorphonuclear elastase determinations in the diagnosis of the severity of acute pancreatitis was analysed in a multicentre study and was compared with the usual prognostic systems of Ranson and Osborne et al. The study comprised 182 patients, 154 with a mild episode of acute pancreatitis and 28 with a severe episode, defined by the development of major complications or a fatal outcome. In the severe cases neutrophilic elastase reached significantly higher values than in mild cases (P less than 0.001) by the time the patient was admitted (2-12 h after the onset of the disease), reflecting considerable leucocyte activation. The sensitivity and specificity of this test are therefore greater than 90 per cent, with a positive severity predictive value of almost 80 per cent at the time of admission and 97 per cent after 24 h, and a negative predictive value of approximately 98 per cent. In addition to requiring 48 h for evaluation, the usual prognostic systems show a sensitivity of 77-85 per cent, a specificity of 70-77 per cent, a positive predictive value of 40-48 per cent, and a negative predictive value of 92-95 per cent, clearly lower than those obtained with leucocyte elastase. Polymorphonuclear elastase is therefore a very early and reliable marker in the diagnosis of the severity of acute pancreatitis, in addition to being easily adaptable to the routine of any hospital laboratory.|
|dc.title||Clinical usefulness of polymorphonuclear elastase in predicting the severity of acute pancreatitis: results of a multicentre study.|
|dc.relation.ispartofjournal||British Journal of Surgery|
|dc.subject.keyword||Core Clinical Journals (AIM), Index Medicus;Acute Disease;Clinical Enzyme Tests;Female;Humans;Leukocyte Elastase;Male;Middle Aged;Pancreatic Elastase/bl [Blood];Pancreatitis/di [Diagnosis];Predictive Value of Tests;Prognosis;Prospective Studies;Sensitivity and Specificity|
|dc.contributor.affiliation||Dominguez-Munoz,J E. Department of Internal Medicine, University Hospital, Guadalajara, Spain.|
|dc.description.note||Record Owner: From MEDLINE, a database of the U.S. National Library of Medicine.; Status: MEDLINE; Publishing Model: Journal available in: Print Citation processed from: Print; NLM Journal Code: b34, 0372553; Registry Number/Name of Substance: EC 3-4-21-36 (Pancreatic Elastase). EC 3-4-21-37 (Leukocyte Elastase).; Entry Date: 19920106|
|Appears in Collections:||Producción científica UdeG (prueba)|
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