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|Title:||XRCC1 polymorphisms and haplotypes in Mexican patients with acute lymphoblastic leukemia|
|Abstract:||Among azoospermics, the activity of seminal a-glucosidase (aG) is low in obstruction (OBS) cases, but there is no agreement regarding its value in others. With the hypothesis that a more marked decrease in aG activity occurs in OBS than in spermatogenesis arrest (SA), the enzyme was measured in the following groups: (1) vasectomized males (n = 15), (2) azoospermics with OBS (n = 7), (3) azoospermics with SA (n = 11), and (4) fertile males (n = 15). Patients within groups 2 and 3 had a testicular volume > 15 mL, no clinical evidence of abnormal epididymis, normal serum gonadotropins, and histological diagnosis. aG activities (mU/g protein, means SD) by group were (1) 131 60, (2) 312 186, (3) 728 303, and (4) 1176 374. All between-group differences were significant (t test, p < 01), except for groups 1 vs. 2 comparison (.05 > p > 01). These results support the notion that SA is associated with a decrease in aG that is less marked than that seen in OBS. The search for germinal epithelium cells in semen also allows discrimination between these two azoospermic groups. " 1995 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.",,,,,,"10.3109/01485019508987867",,,"http://hdl.handle.net/20.500.12104/45781","http://www.scopus.com/inward/record.url?eid=2-s2.0-84907131996&partnerID=40&md5=ab1d7788f81d0b091cabfacedd28409a",,,,,,"2",,"Systems Biology in Reproductive Medicine",,"155|
158",,"35",,"Scopus",,,,,,"A-glucosidase; Azoospermic; Diagnosis; Male infertility; Meiosis; Semen analysis",,,,,,"?1,4-glucosidase activity and the presence of germinal epithelium cells in the semen for differential diagnosis of obstructive and nonobstructive azoospermia",,"Article" "47538","123456789/35008",,"Meza-Espinoza, J.P., Unidad Academica de Ciencias de la Salud Y Tecnologia, Universidad Autonoma de Tamaulipas, Matamoros, Tamps, Mexico; Peralta-Leal, V., Unidad Academica de Ciencias de la Salud Y Tecnologia, Universidad Autonoma de Tamaulipas, Matamoros, Tamps, Mexico; Gutierrez-Angulo, M., Centro Universitario de Los Altos, Universidad de Guadalajara, Tepatitlan de Morelos, Jalisco, Mexico; Macias-Gomez, N., Centro Universitario del Sur, Universidad de Guadalajara, Cd. Guzman, Jalisco, Mexico; Ayala-Madrigal, M.L., Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; Barros-Nuñez, P., Centro de Investigacion Biomedica de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, Mexico; Duran-Gonzalez, J., University of Texas at Brownsville, Brownsville, TX, United States; Leal-Ugarte, E., Unidad Academica de Ciencias de la Salud Y Tecnologia, Universidad Autonoma de Tamaulipas, Matamoros, Tamps, Mexico",,"Meza-Espinoza, J.P.
Leal-Ugarte, E.",,"2009",,"We examined the influence of the Arg194Trp, Arg280His, and Arg399Gln polymorphisms of XRCC1 (X-ray repair cross-complementing group 1) on the development of childhood acute lymphoblastic leukemia (ALL) in 120 ALL patients and 120 controls in Mexico. All of them were genotyped for these polymorphisms, using polymerase chain reaction. No significant differences in allele and genotype frequencies for any polymorphism were observed between patients and controls. Estimation of haplotypes showed the eight expected haplotypes (A-H), seven of which were found in both patients and controls; haplotype A (Arg-Arg-Arg) was the most common, whereas haplotypes F and G were absent in patients and controls, respectively. Haplotype B (Trp-Arg-Arg) was found to be associated with an increased risk of ALL (odds ratio (OR) = 1.95, 95% confidence interval (CI) = 1.13-3.37; P = 0.016), particularly in males (OR = 2.65, 95%CI = 1.25-5.63; P = 0.01). Individually, the 194Trp, 280His, and 399Gln alleles were not associated with significantly increased risk for ALL in these Mexican children. " FUNPEC-RP.
|Appears in Collections:||Producción científica UdeG|
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