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Title: Theophylline release from poly(acrylic acid-co-acrylamide) hydrogels
Author: Katime, I.
Novoa, R.
Diaz De Apodaca, E.
Mendizábal, E. M.
Puig, J.
Issue Date: 1999
Abstract: Hydrogels are hydrophilic polymers that swell to an equilibrium volume in the presence of water but preserve their shape. The dynamic swelling behavior of poly(acrylic acid-co-acrylamide) copolymers, at 37 °C, was investigated. It was observed that the liberation mechanism was non-Fickian. Diffusion coefficients according to Ficks law as a function of concentration of N,N?-methylenebisacrylamide and results on the effects of crosslink density on the release of theophylline are reported.
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