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|Title:||The young stellar population of IC 1613 I. A new catalogue of OB associations|
|Abstract:||Tuberculosis causes close to 1.5 million deaths in the world, with new cases exceeding 9 million in recent years. Coinfection with HIV further worsens the global situation. New molecules that overcome the limitations of currently used drugs are needed. We aimed to determine whether HHC-10 is active against the Mycobacterium tuberculosis complex bacteria Mycobacterium bovis bacille calmette guerin (BCG) in vitro and in vivo. For this, HHC-10 was tested in vitro using different peptide concentrations, and in vivo, in C57BL/6 mice infected intratracheally, at two doses (1.25 and 2.5 mg kg-1, once a week, 4 weeks). Interferon (IFN)-?, TNF-?, interleukin (IL)-4, and IL-10 mRNA transcript levels were compared between treated and nontreated mice. In vitro, HHC-10 decreased 69% and 88% the number of colony-forming units (CFU) per millileter recovered after 24-hr treatment at 50 and 100 ?g/ml, respectively. In vivo, BCG CFUs in mouse lungs were reduced 77.8% and 95.8% at 1.25 and 2.5 mg kg-1, respectively. IFN-? expression was lower in the HHC-10-treated group than that of nontreated animals. Considering genomic conservation between BCG and M. tuberculosis, the in vitro and in vivo activities of HHC-10 observed in this study suggest that the use of this peptide may be useful as therapeutic agent against tuberculosis. " Copyright 2013, Mary Ann Liebert, Inc. 2013.",,,,,,"10.1089/mdr.2012.0149",,,"http://hdl.handle.net/20.500.12104/45299","http://www.scopus.com/inward/record.url?eid=2-s2.0-84875624049&partnerID=40&md5=d87ed563e26de471aed5816616435baa",,,,,,"2",,"Microbial Drug Resistance",,"124|
WOS",,,,,,,,,,,,"The synthetic cathelicidin HHC-10 inhibits mycobacterium bovis BCG in vitro and in C57BL/6 mice",,"Article" "47083","123456789/35008",,,,,,"2002",,,,,,,,"10.1021/es0222465",,"0013-936X","http://hdl.handle.net/20.500.12104/45304","http://dx.doi.org/10.1021/es0222465",,,,"American Chemical Society",,"7",,"Environmental science & technology",,"131A
131A",,"36",,"ChemAbsS",,,,,,,,,,,,"News Briefs: Over the next 100 years, changes in climate will pose serious risks for inland freshwater ecosystems and coastal wetlands in the United States,",,"Journal Article" "47102","123456789/35008",,"García, M., Instituto de Astrofísica de Canarias, Vía Láctea s/n, 38200 La Laguna, Tenerife, Spain; Herrero, A., Instituto de Astrofísica de Canarias, Vía Láctea s/n, 38200 La Laguna, Tenerife, Spain, Dpto. de Astrofísica, Universidad de la Laguna, Avda. Astrofísico Francisco Sánchez s/n, 38071 La Laguna, Tenerife, Spain; Vicente, B., Instituto de Astrofísica de Canarias, Vía Láctea s/n, 38200 La Laguna, Tenerife, Spain, Instituto de Astrofísica de Andalucía, CSIC, Apdo. 3004, 18080 Granada, Spain; Castro, N., Instituto de Astrofísica de Canarias, Vía Láctea s/n, 38200 La Laguna, Tenerife, Spain, Dpto. de Astrofísica, Universidad de la Laguna, Avda. Astrofísico Francisco Sánchez s/n, 38071 La Laguna, Tenerife, Spain; Corral, L.J., Instituto de Astronomía y Meteorología, Universidad de Guadalajara, Av. Vallarta No. 2602, Guadalajara, Jalisco, CP 44130, Mexico; Rosenberg, A., Instituto de Astrofísica de Canarias, Vía Láctea s/n, 38200 La Laguna, Tenerife, Spain; Monelli, M., Instituto de Astrofísica de Canarias, Vía Láctea s/n, 38200 La Laguna, Tenerife, Spain",,"García, M.
Monelli, M.",,"2009",,"Context. Determining the parameters of massive stars is crucial to understand many processes in galaxies and the Universe, since these objects are important sources of ionization, chemical enrichment and momentum. 10m class telescopes enable us to perform detailed quantitative spectroscopic analyses of massive stars in other galaxies, sampling areas of different metallicity. Relating the stars to their environment is crucial to understand the physical processes ruling their formation and evolution. Aims. In preparation for the new instrumentation planned for the Gran Telescopio CANARIAS (GTC), our goal is to build a list of massive star candidates in the metal-poor irregular galaxy IC 1613. The catalogue must have very high astrometric accuracy, suitable for the current generation of multi-object spectrographs. A census of OB associations in this galaxy is also needed, to provide important additional information about the age and environment of the candidate OB stars. Methods. From observations taken with the Wide Field Camera (WFC) at the Isaac Newton Telescope (INT), we have built an astrometric and photometric catalogue of stars in IC 1613. Candidate blue massive stars are preselected by their colors. A friendsof-friends algorithm is developed to find their clustering in the galaxy. While a common physical origin for all the members of the associations cannot be ensured, this is a necessary first step to place candidate OB stars in a population context. Results. We have produced a deep catalogue of targets in IC 1613 that covers a large field of view. To achieve high astrometric accuracy, a new astrometric procedure was developed for the INT-WFC data. We also built a catalogue of OB associations in IC 1613 and found that they concentrate in the central regions, especially in the HII bubbles. The study of extinction confirms that it is patchy, with local values of color-excess above the foreground value. " ESO 2009.
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