Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/45267
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dc.contributor.authorSalguero, M.L.
dc.contributor.authorLeon, R.E.
dc.contributor.authorSantos, A.
dc.contributor.authorRoman, S.
dc.contributor.authorSegura-Ortega, J.E.
dc.contributor.authorPanduro-Cerda, Arturo
dc.date.accessioned2015-09-15T19:10:16Z-
dc.date.available2015-09-15T19:10:16Z-
dc.date.issued2005
dc.identifier.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-29144535770&partnerID=40&md5=796f8bf9dd35a50982bd56041bdaf204
dc.identifier.urihttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=16289894
dc.identifier.urihttp://hdl.handle.net/20.500.12104/45267-
dc.description.abstractHypertriglyceridemia and dietary lipids have been suggested to modulate the severity of alcoholic liver disease and the progression to alcoholic cirrhosis (AC). The intestinal fatty acid binding protein (IFABP) is the main transporter of dietary fatty acids into the enterocyte and has a genetic polymorphism, FABP2 A54T that has been associated with hypertriglyceridemia. We determined the frequency of the FABP2 gene polymorphism using PCR-RFLP and measured serum triglycerides, HDL, LDL, total lipids and cholesterol in 67 patients with AC and in 124 unrelated healthy individuals. Frequencies of genotypes and alleles were similar between the two groups. The healthy subjects, who were homozygous for the Thr54 genotype had significantly higher mean triglyceride serum concentrations than those homozygous for the Ala54 genotype (P < 0.05). However, AC patients who were homozygous for the Thr54 genotype, had lower mean triglyceride serum concentrations (P < 0.01), and had a significantly longer period of continued alcohol abuse prior to the diagnosis of liver cirrhosis compared to the AC patients homozygous for the Ala54 genotype (P < 0.05). Our data suggests that the polymorphism Thr54 of the FABP2 gene is associated with a later onset of AC in the lower economic status Mexican population studied. � 2005 Elsevier Ireland Ltd. All rights reserved.
dc.relation.isreferencedbyScopus
dc.relation.isreferencedbyWOS
dc.relation.isreferencedbyMEDLINE
dc.titleThe role of FABP2 gene polymorphism in alcoholic cirrhosis
dc.typeArticle
dc.identifier.doi10.1016/j.hepres.2005.09.037
dc.relation.ispartofjournalHepatology Research
dc.relation.ispartofvolume33
dc.relation.ispartofissue4
dc.relation.ispartofpage306
dc.relation.ispartofpage312
dc.subject.keywordAlcohol; Cirrhosis; Economic status; FABP2; Lipid; Mexican
dc.contributor.affiliationSalguero, M.L., Department of Molecular Biology, Civil Hospital of Guadalajara Fray Antonio Alcalde, University of Guadalajara, P.O. Box 2-500, Guadalajara, 44280 Jalisco, Mexico, Institute of Molecular Biology in Medicine, University of Guadalajara, Sierra Mojada 950, Guadalajara, 44340 Jalisco, Mexico; Leon, R.E., Department of Molecular Biology, Civil Hospital of Guadalajara Fray Antonio Alcalde, University of Guadalajara, P.O. Box 2-500, Guadalajara, 44280 Jalisco, Mexico, Institute of Molecular Biology in Medicine, University of Guadalajara, Sierra Mojada 950, Guadalajara, 44340 Jalisco, Mexico; Santos, A., Department of Molecular Biology, Civil Hospital of Guadalajara Fray Antonio Alcalde, University of Guadalajara, P.O. Box 2-500, Guadalajara, 44280 Jalisco, Mexico, Institute of Molecular Biology in Medicine, University of Guadalajara, Sierra Mojada 950, Guadalajara, 44340 Jalisco, Mexico, Institute of Ophthalmology and Visual Sciences, University of Guadalajara, Sierra Mojada 950, Guadalajara, 44340 Jalisco, Mexico; Roman, S., Department of Molecular Biology, Civil Hospital of Guadalajara Fray Antonio Alcalde, University of Guadalajara, P.O. Box 2-500, Guadalajara, 44280 Jalisco, Mexico, Institute of Molecular Biology in Medicine, University of Guadalajara, Sierra Mojada 950, Guadalajara, 44340 Jalisco, Mexico; Segura-Ortega, J.E., Department of Molecular Biology, Civil Hospital of Guadalajara Fray Antonio Alcalde, University of Guadalajara, P.O. Box 2-500, Guadalajara, 44280 Jalisco, Mexico, Institute of Molecular Biology in Medicine, University of Guadalajara, Sierra Mojada 950, Guadalajara, 44340 Jalisco, Mexico; Panduro, A., Department of Molecular Biology, Civil Hospital of Guadalajara Fray Antonio Alcalde, University of Guadalajara, P.O. Box 2-500, Guadalajara, 44280 Jalisco, Mexico, Institute of Molecular Biology in Medicine, University of Guadalajara, Sierra Mojada 950, Guadalajara, 44340 Jalisco, Mexico
dc.contributor.affiliationPanduro-Cerda, Arturo., Universidad de Guadalajara. Centro Universitario de Ciencias de la Salud
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