Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/45032
Title: The 3?UTR 1188 A/C polymorphism in the interleukin-12p40 gene (IL-12B) is associated with lepromatous leprosy in the west of Mexico
Author: Medina-Gutierrez, C.
Quintanar, J.L.
Frausto-Reyes, C.
Sato-Berru, R.
Issue Date: 2005
Abstract: Serum blood samples of euthyroid and thyroidectomized rats treated with thyrotropin-releasing hormone (TRH) were analyzed on aluminum substrates using the near-infrared Raman spectroscopy (830 nm). Spectra of thyroid-stimulating hormone (TSH), TRH and prolactin standards were obtained. Differences between Raman spectra profiles of control and Tx + TRH samples groups were found. These differences were confirmed by the linear discriminant analysis (LDA), which presents a good classification between groups. It is supposed that these differences are produced by the increment of TSH in the thyroidectomized rats. " 2004 Elsevier B.V. All rights reserved.",,,,,,"10.1016/j.saa.2004.03.016",,,"http://hdl.handle.net/20.500.12104/45032","http://www.scopus.com/inward/record.url?eid=2-s2.0-9544237139&partnerID=40&md5=1c57c3f016e93cdca87e42d8aaabf358",,,,,,"01-feb",,"Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy",,"87
91",,"61",,"Scopus
WOS",,,,,,"Near-infrared raman spectroscopy; Prolactin; TRH; TSH",,,,,,"The application of NIR Raman spectroscopy in the assessment of serum thyroid-stimulating hormone in rats",,"Article" "46790","123456789/35008",,"Aguilar, B.B., Departamento de Madera, Celulosa y Papel, Universidad de Guadalajara",,"Aguilar, B.B.",,"2007",,"[No abstract available]",,,,,,,,,"http://hdl.handle.net/20.500.12104/45011","http://www.scopus.com/inward/record.url?eid=2-s2.0-44449137072&partnerID=40&md5=063033f23a4e22531e1b5cb95297475b",,,,,,"3",,"Mari Papel y Corrugado",,"40
41",,"20",,"Scopus",,,,,,,,,,,,"The "former" also requires attention Importance of the distribution chest [El "formador" también requiere atención. Importancia de la caja distribuidora]",,"Article" "46798","123456789/35008",,"Alvarado-Navarro, A., Centro de Investigación en Inmunología y Dermatología, Departamento de Fisiología, Centro Universitario de Ciencias de la Salud, Guadalajara, Jalisco, Mexico; Montoya-Buelna, M., Centro de Investigación en Inmunología y Dermatología, Departamento de Fisiología, Centro Universitario de Ciencias de la Salud, Guadalajara, Jalisco, Mexico; Muñoz-Valle, J.F., Instituto de Investigacion en Reumatologia y del Sistema Musculo Esqueletico, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; López-Roa, R.I., Centro de Investigación en Inmunología y Dermatología, Departamento de Fisiología, Centro Universitario de Ciencias de la Salud, Guadalajara, Jalisco, Mexico; Guillen-Vargas, C., Centro de Investigación en Inmunología y Dermatología, Departamento de Fisiología, Centro Universitario de Ciencias de la Salud, Guadalajara, Jalisco, Mexico; Fafutis-Morris, M., Centro de Investigación en Inmunología y Dermatología, Departamento de Fisiología, Centro Universitario de Ciencias de la Salud, Guadalajara, Jalisco, Mexico",,"Alvarado-Navarro, A.
Montoya-Buelna, M.
Munoz-Valle, J.F.
Lopez-Roa, R.I.
Guillen-Vargas, C.
Fafutis-Morris, M.",,"2008",,"Leprosy is a chronic infectious disease caused by Mycobacterium leprae. IL-12 participates in the immune response against M. leprae by regulating T cell differentiation into the Th1-type response. Several single nucleotide polymorphisms have been identified in the IL-12 gene such as 3?UTR 1188 A/C polymorphism, which is associated with different diseases. However, the relationship of this polymorphism with the immune response in leprosy has not been explored. In this case-control study, we evaluated 44 patients with lepromatous leprosy (LL) and 51 healthy subjects (HS). We aimed to determine the relationship between 3?UTR 1188 A/C polymorphism of IL-12 p40, mRNA expression, and soluble IL-12 concentration in LL patients and HS. Genotype frequencies were 41% A/A, 36% A/C, and 23% C/C in LL patients, and 47% A/A, 49% A/C, and 4% C/C in HS (p < 0.05). LL patients had a lower mRNA expression of IL-12 p40 gene, whereas HS had a higher expression level. Soluble IL-12 p40 concentration was higher in LL patients than in HS (p < 0.05). IL-12 p70 concentration did not differ between groups, and IL-12 p40 concentration was not significantly correlated with mRNA expression in either group. These data suggest that IL-12 p40 3?UTR 1188 A/C polymorphism is associated with greater susceptibility to lepromatous leprosy in patients from western Mexico, independently of IL-12 p40 and p70 expression levels. " 2008 Elsevier B.V. All rights reserved.
URI: http://hdl.handle.net/20.500.12104/45019
http://www.scopus.com/inward/record.url?eid=2-s2.0-44649110802&partnerID=40&md5=060c4c9d5eb7a68a92fbc4f593d39e42
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