Por favor, use este identificador para citar o enlazar este ítem: https://hdl.handle.net/20.500.12104/45024
Título: The A431E mutation in PSEN1 causing Familial Alzheimer's Disease originating in Jalisco State, Mexico: An additional fifteen families
Autor: Murrell, J.
Ghetti, B.
Cochran, E.
Macias-Islas, M.A.
Medina, L.
Varpetian, A.
Cummings, J.L.
Mendez, M.F.
Kawas, C.
Chui, H.
Ringman, J.M.
Fecha de publicación: 2006
Resumen: Nine families with autosomal dominant Alzheimer's disease (AD), all of whom had the Ala431Glu substitution in the PSEN1 gene and came from Jalisco State in Mexico, have been previously reported. As they shared highly polymorphic flanking dinucleotide marker alleles, this strongly suggests that this mutation arose from a common founder. In the current letter, we expand this observation by describing an additional 15 independent families with the Ala431Glu substitution in the PSEN1 gene and conclude that this mutation is not an uncommon cause of early-onset autosomal dominant AD in persons of Mexican origin. � Springer-Verlag 2006.
URI: http://www.scopus.com/inward/record.url?eid=2-s2.0-33750037617&partnerID=40&md5=2d671fc5f0bfee44d8e0187e6baa26b6
http://hdl.handle.net/20.500.12104/45024
Aparece en las colecciones:Producción científica UdeG

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