Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/44958
Title: Tamoxifen favoured the rat sensorial cortex regeneration after a penetrating brain injury
Author: Franco Rodriguez, N.E.
Duenas Jimenez, J.M.
De la Torre Valdovinos, B.
Lopez Ruiz, J.R.
Hernandez Hernandez, L.
Duenas Jimenez, S.H.
Issue Date: 2013
Abstract: A penetrating brain injury produces a glial scar formed by astrocytes, oligodendrocytes, microglia and NG2 cells. Glial scar is a barrier preventing the extent of damage but it has deleterious effects in the regeneration of the axons. Estradiol and tamoxifen reduce gliosis and have neuroprotective effects in the hippocampus and the spinal cord. We evaluated the proliferation of glia and the electrocorticogram in the sensorial cortex in a brain injury model. At seven days post-injury, estradiol, tamoxifen and estradiol plus tamoxifen reduced the number of resident and proliferative NG2 and reactive astrocyte vimentin+ cells. Estradiol and tamoxifen effects on NG2 cells could be produced by the classical oestrogen receptors found in these cells. The glial scar was also reduced by tamoxifen. At thirty days post-injury, the amount of resident and proliferative astrocytes increased significantly, except in the estradiol plus tamoxifen group, whilst the oligodendrocytes proliferation in the glial scar was reduced in treated animals. Tamoxifen promotes the survival of FOX-3+ neurons in the injured area and a recovery in the amplitude of electrocorticogram waves. At thirty days, estradiol did not favour the suvival of neurons but produced a greater number of reactive astrocytes. In contrast, the number of oligodendrocytes was reduced. Tamoxifen could favour brain repair promoting neuron survival and adjusting glial cell number. It seems to recover adequate neural communication. � 2013 Elsevier Inc..
URI: http://www.scopus.com/inward/record.url?eid=2-s2.0-84882630873&partnerID=40&md5=40bb40d020540c374ac3e785aca69767
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=23886572
http://hdl.handle.net/20.500.12104/44958
Appears in Collections:Producción científica UdeG

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