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Title: Synthesis and characterization of a hybrid (chitosan-g-glycidyl methacrylate)-xanthan hydrogel
Author: Gutierrez-Mejia, A.
Herrera-Kao, W.
Duarte-Aranda, S.
Loria-Bastarrachea, M.I.
Canche-Escamilla, G.
Moscoso-Sanchez, F.J.
Cauich-Rodriguez, J.V.
Cervantes-Uc, J.M.
Issue Date: 2013
Abstract: Core-shell nanoparticles consisting of polybutyl acrylate (PBA) rubbery core and a polymethyl methacrylate (PMMA) shell, with different core-shell ratios, were synthesized in order to enhance the fracture toughness of the acrylic bone cements prepared with them. It was observed by TEM and SEM that the core-shell nanoparticles exhibited a spherical morphology with ca. 120 nm in diameter and that both modulus and tensile strength decreased by increasing the PBA content; the desired structuring pattern in the synthesized particles was confirmed by DMA. Also, experimental bone cements were prepared with variable amounts (0, 5, 10 and 20 wt.%) of nanoparticles with a core-shell ratio of 30/70 in order to study the influence of these nanostructured particles on the physicochemical, mechanical and fracture properties of bone cements. It was found that the addition of nanostructured particles to bone cements caused a significant reduction in the peak temperature and setting time while the glass transition temperature (Tg) of cements increased with increasing particles content. On the other hand, modulus and strength of bone cements decreased when particles were incorporated but fracture toughness was increased. " 2012 Elsevier B.V. All Rights Reserved.",,,,,,"10.1016/j.msec.2012.12.087",,,"","",,,,,,"3",,"Materials Science and Engineering C",,"1737
WOS",,,,,,"Bone cements; Core-shell nanoparticles; Mechanical properties",,,,,,"Synthesis and characterization of core-shell nanoparticles and their influence on the mechanical behavior of acrylic bone cements",,"Article" "46696","123456789/35008",,"Elizalde-Peña, E.A., CINVESTAV, Unidad Querétaro, Libramiento Norponiente No. 2000, Frac. Real de Juriquilla, Querétaro, Qro. 76230, Mexico; Zarate-Triviño, D.G., CINVESTAV, Unidad Querétaro, Libramiento Norponiente No. 2000, Frac. Real de Juriquilla, Querétaro, Qro. 76230, Mexico; Nuño-Donlucas, S.M., Departamento de Ingeniería Química, Universidad de Guadalajara, Guadalajara, Jal. 44430, Mexico; Medina-Torres, L., Chemistry Faculty e, Enginnering Department, National Autonomous University of Mexico, México City, 04510, Mexico; Gough, J.E., School of Materials: Materials Science Centre, University of Manchester, Grosvenor Street, Manchester, M1 7HS, United Kingdom; Sanchez, I.C., Department of Chemical Engineering, University of Texas at Austin, Austin, TX 78712, United States; Villaseñor, F., Department of Biochemical Engineering, Instituto Tecnologico de Celaya, Gto, Celaya, Mexico; Luna-Barcenas, G., CINVESTAV, Unidad Querétaro, Libramiento Norponiente No. 2000, Frac. Real de Juriquilla, Querétaro, Qro. 76230, Mexico",,"Elizalde-Pena, E.A.
Zarate-Trivino, D.G.
Nuno-Donlucas, S.M.
Medina-Torres, L.
Gough, J.E.
Sanchez, I.C.
Villasenor, F.
Luna-Barcenas, G.",,"2013",,"This work reports the synthesis and characterization of a new material obtained by mixing the hybrid natural-synthetic chitosan-g-glycidyl methacrylate (CTS-g-GMA) biopolymer and xanthan gum (X). All materials were characterized by infrared spectroscopy (FTIR), X-ray diffraction, and thermal analysis (DSC and TGA) and the results were contrasted with those of the precursor materials. The swelling index of the hydrogels decreases when the GMA mass percentage increases. The X-ray diffraction patterns show that the hybrid hydrogels are amorphous in contrast to chitosan (CTS), which is semi-crystalline. FTIR analysis confirms the existence of physical interactions among constituents. Rheological properties, ?, G?, and G?, were determined as a function of flow allowing one to conclude that (CTS-g-GMA)-X behaves as physical hydrogel. Additionally, we report viability of fibroblasts when cultured onto the synthesized hydrogels. This study shows that these hydrogels support cell viability and have potential for use in biomedical engineering applications. " 2013 Copyright Taylor & Francis Group, LLC.
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