Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/44635
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dc.contributor.authorBollain-Y-Goytia, J.J.
dc.contributor.authorArellano-Rodriguez, M.
dc.contributor.authorTorres-Del-Muro, F.D.J.
dc.contributor.authorDaza-Benitez, L.
dc.contributor.authorFrancisco Munoz-Valle, J.
dc.contributor.authorAvalos-Diaz, E.
dc.contributor.authorHerrera-Esparza, R.
dc.date.accessioned2015-09-15T18:58:13Z-
dc.date.available2015-09-15T18:58:13Z-
dc.date.issued2014
dc.identifier.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-84914689454&partnerID=40&md5=c421051223fe708686d6c59cf934a186
dc.identifier.urihttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=25505993
dc.identifier.urihttp://hdl.handle.net/20.500.12104/44635-
dc.description.abstractThis study was performed to clarify the role of soluble Fas (sFas) in lupus nephritis (LN) and establish a potential relationship between LN and the -670 polymorphism of Fas in 67 patients with systemic lupus erythematosus (SLE), including a subset of 24 LN patients with proteinuria. Additionally, a group of 54 healthy subjects (HS) was included. The allelic frequency of the -670 polymorphism of Fas was determined using PCR-RFLP analysis, and sFas levels were assessed by ELISA. Additionally, the WT-1 protein level in urine was measured. The Fas receptor was determined in biopsies by immunohistochemistry (IHC) and in situ hybridization (FISH) and apoptotic features by TUNEL. Results. The -670 Fas polymorphism showed that the G allele was associated with increased SLE susceptibility, with an odds ratio (OR) of 1.86. The sFas was significantly higher in LN patients with the G/G genotype, and this subgroup exhibited correlations between the sFas level and proteinuria and increased urinary WT-1 levels. LN group shows increased expression of Fas and apoptotic features. In conclusion, our results indicate that the G allele of the -670 polymorphism of Fas is associated with genetic susceptibility in SLE patients with elevated levels of sFas in LN with proteinuria. � 2014 Juan Jos� Bollain-y-Goytia et al.
dc.relation.isreferencedbyScopus
dc.relation.isreferencedbyMEDLINE
dc.titleSoluble Fas and the -670 polymorphism of Fas in lupus nephritis
dc.typeArticle
dc.identifier.doi10.1155/2014/780406
dc.relation.ispartofjournalInternational Journal of Nephrology
dc.relation.ispartofvolume2014
dc.contributor.affiliationBollain-Y-Goytia, J.J., Laboratorios de Inmunolog�a y Biolog�a Molecular, UA Ciencias Biol�gicas, Universidad Aut�noma de ZacatecasZacatecas, ZAC, Mexico; Arellano-Rodr�guez, M., Laboratorios de Inmunolog�a y Biolog�a Molecular, UA Ciencias Biol�gicas, Universidad Aut�noma de ZacatecasZacatecas, ZAC, Mexico; Torres-Del-Muro, F.D.J., Laboratorios de Inmunolog�a y Biolog�a Molecular, UA Ciencias Biol�gicas, Universidad Aut�noma de ZacatecasZacatecas, ZAC, Mexico; Daza-Ben�tez, L., Unidad M�dica de Alta Especialidad (UMAE) HPG No. 48, Instituto Mexicano Del Seguro Social (IMSS)Le�n, GTO, Mexico; Francisco Mu�oz-Valle, J., Instituto de Investigaci�n en Ciencias Biom�dicas, Centro Universitario de Ciencias de la Salud, Universidad de GuadalajaraGuadalajara, JAL, Mexico; Avalos-D�az, E., Laboratorios de Inmunolog�a y Biolog�a Molecular, UA Ciencias Biol�gicas, Universidad Aut�noma de ZacatecasZacatecas, ZAC, Mexico; Herrera-Esparza, R., Laboratorios de Inmunolog�a y Biolog�a Molecular, UA Ciencias Biol�gicas, Universidad Aut�noma de ZacatecasZacatecas, ZAC, Mexico
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