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|Title:||Small grain size zirconium-based coatings deposited by magnetron sputtering at low temperatures|
|Author:||Prado-Montes de Oca, E.|
|Abstract:||Leprosy is an infectious disease caused by Mycobacterium leprae. The peptide human ?-defensin 1 is an antimicrobial effector of innate epithelial immunity. A study was done on the association of three single nucleotide polymorphisms (SNPs) in the ?-defensin 1 gene (DEFB1) - 668 C/G (-44 C/G or rs1800972; in 5? UTR), 692 A/G (-20 A/G or rs11362; in 5? UTR) and A1836G (rs1800971; in 3? UTR) - with leprosy susceptibility per se and clinical leprosy variants. The SNPs were genotyped by real-time polymerase chain reaction (rt-PCR) and PCR-restriction fragment length polymorphisms. Subjects were of Mexican mestizo ethnicity from Sinaloa state, México. Analysis was done on borderline leprosy, lepromatous leprosy (L-lep) and indeterminate leprosy subgroups compared with healthy controls. Results: The genotypes associated with L-lep and no other leprosy subgroup after Bonferroni correction were those that contain 668C in a dominant model (OR = 3.06, 95% CI 1.47-6.4, p = 0.024). Estimated haplotype CGA is over-represented in L-lep (p = 0.009; OR = 2.25, 1.23-4.03). Five NF-?B1 putative binding sites (NPBSs) were identified with JASPAR software in non-coding strand spanning the 5? UTR and intron 1 of DEFB1, including one which is altered when SNP 668C is present. SNP 668C probably abrogates NF-?B-dependent DEFB1 upregulation leading to L-lep variant. " 2009.",,,,,,"10.1016/j.meegid.2009.03.006",,,"http://hdl.handle.net/20.500.12104/44594","http://www.scopus.com/inward/record.url?eid=2-s2.0-68649115023&partnerID=40&md5=2abfc02faaf4716b6f8ea5d93b414410|
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med5&AN=19460328",,,,,,"4",,"Infection, Genetics and Evolution",,"617
WOS",,,,"Index Medicus;Base Sequence;Binding Sites;Chi-Square Distribution;Genetic Predisposition to Disease;Haplotypes;Humans;Leprosy, Lepromatous/ge [Genetics];Leprosy, Lepromatous/im [Immunology];Linkage Disequilibrium;Mexico;Models, Genetic;Molecular Sequence Data;NF-kappa B/me [Metabolism];Polymorphism, Restriction Fragment Length;Polymorphism, Single Nucleotide;Protein Binding;Reverse Transcriptase Polymerase Chain Reaction;beta-Defensins/ge [Genetics]",,"hBD-1, human beta defensin, NF-kappa B, SNP; Innate immunity, Mycobacterium leprae, defensins; Lepromatous leprosy susceptibility, L-lep, DEFB1",,,,,,"SNP 668C (-44) alters a NF-?B1 putative binding site in non-coding strand of human ?-defensin 1 (DEFB1) and is associated with lepromatous leprosy",,"Article" "46366","123456789/35008",,"Jimenez, O., Departamento de Ingeniería de Proyectos, CUCEI, Universidad de Guadalajara, AP 307, CP 45101 Zapopan, Jalisco, Mexico, Department of Engineering Materials, The University of Sheffield, Sheffield S1 3JD, UK; Audronis, M., Department of Engineering Materials, The University of Sheffield, Sheffield S1 3JD, UK; Leyland, A., Department of Engineering Materials, The University of Sheffield, Sheffield S1 3JD, UK; Flores, M., Departamento de Ingeniería de Proyectos, CUCEI, Universidad de Guadalajara, AP 307, CP 45101 Zapopan, Jalisco, Mexico; Rodriguez, E., Departamento de Ingeniería de Proyectos, CUCEI, Universidad de Guadalajara, AP 307, CP 45101 Zapopan, Jalisco, Mexico; Kanakis, K., Department of Engineering Materials, The University of Sheffield, Sheffield S1 3JD, UK; Matthews, A., Department of Engineering Materials, The University of Sheffield, Sheffield S1 3JD, UK",,"Jimenez, O.
Matthews, A.",,"2014",,"Hard partly amorphous, ceramic physical vapour deposition ZrTiN(B) coatings were deposited onto (111) silicon wafers at substrate temperatures of 85 and 110 °C using closed field unbalanced magnetron sputtering. A rectangular sputter target composed of three pieces (Zr/TiB2/Zr) was used as the source of evaporation of coating components. Two different substrate biases (i.e. floating potential and - 50 V) and N2 flow rates of 2, 4 and 6 sccm were employed as deposition parameters. The chemical composition, structure, morphology and mechanical properties were investigated using a variety of analytical techniques such as glow-discharge optical emission spectroscopy, cross-sectional scanning electron microscopy (SEM), grazing angle X-ray diffraction (GAXRD) and nanoindentation. Coating properties were found to be dependent on deposition parameters (i.e. nitrogen flow rate and substrate negative bias). Linear scan profiles and SEM imaging revealed that all coatings were superficially smooth, dense and featureless (cross section fracture) with no apparent macro-defects. Structural analysis by GAXRD revealed that mostly metallic phases were formed for coatings containing no nitrogen. Whereas a solid solution Zr(Ti)N single phase was found in most of the reactively deposited coatings with very small grain sizes due to nitrogen and boron grain refinement effect. The hardness increment from 8.6 GPa to 25.9 GPa is related to the solid solution strengthening effect. The elastic modulus correlated well with the hardness behaviour; values in the range of 120-200 GPa were observed depending on the deposition parameters. " 2014 Elsevier B.V. All rights reserved.
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