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|Title:||Significance of linkage disequilibrium heterogeneous patterns in the 21q22.3 region for mapping 21 trisomy individuals|
|Author:||Klimov, Andrei B.|
|Abstract:||Depolarization of quantum fields is handled through a master equation of the Lindblad type. The specific feature of the model is that it couples the field modes to a randomly distributed atomic bath dispersively. The depolarizing dynamics emerging from this approach is analyzed for relevant states. " 2006 Optical Society of America.",,,,,,"10.1364/JOSAB.23.000126",,,"http://hdl.handle.net/20.500.12104/44542","http://www.scopus.com/inward/record.url?eid=2-s2.0-33644600074&partnerID=40&md5=14443c46c4c17d3fa6bd0d0e620cdeea",,,,,,"1",,"Journal of the Optical Society of America B: Optical Physics",,"126|
WOS",,,,,,,,,,,,"Simple quantum model for light depolarization",,"Article" "46311","123456789/35008",,"Valle, Y., Departamento de Clínicas Médicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Mexico; Padilla-Gutiérrez, J.R., Departamento de Clínicas Médicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Mexico; Quintero-Ramos, A., Departamento de Fisiología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Mexico; García-González, I.J., Doctorado en Genética Humana, CUCS, Universidad de Guadalajara, Guadalajara, Mexico; Rivas, F., Hospital General de Occidente, Secretaría de Salud Jalisco, Guadalajara, Mexico",,"Valle, Y.
Rivas, F.",,"2013",,"Recombination patterns can be indirectly inferred by means of linkage disequilibrium (LD) estimates, since LD is negatively correlated with genetic distance. However, LD does not necessarily have absolute correspondence with genetic distance. We estimated LD at 5 loci located in the 21q22.3 region. These STRs (D21S1440, D21S168, D21S1260, D21S1446, and D21S1411) covered 8.81 Mb of the 21q22.3 region. They were genotyped by conventional PCR. Similar size samples previously validated by sequencing were used as a genotyping control. Three hundred and sixty-nine individuals (62 families) living in Guadalajara, Mexico, were included. As an inclusion criterion, each family had a positive paternity test by autosomal markers for the CODIS core loci. Two hundred and thirty phase known haplotypes were identified by familial segregation. Only those haplotypes whose frequency was higher than 4% were taken into account for LD estimation, expressed as Lewontin's D' coefficient and Bonferroni's correction P values. For all 5 loci, the genetic distributions were in agreement with Hardy-Weinberg expectations. Heterozygosity and haplotype diversity were ?0.69 and 99.58%, respectively. D21S1440-D21S168 (4.51 cM) and D21S1446-D21S1411 (4.58 cM) marker haplotype frequencies were significantly different from those expected by random distribution. The remaining haplotypes, including those with minimal inter-distance (D21S1260-D21S1446, 1.44 Mb), did not show LD. The 5 STRs at the 21q22.3 region in this Mexican population showed a non-homogeneous LD pattern, which demonstrates that recombination or linkage should not be assumed solely on the basis of genetic distance. "FUNPEC-RP www.funpecrp.com.br.
|Appears in Collections:||Producción científica UdeG|
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