Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/44502
Full metadata record
DC FieldValueLanguage
dc.contributor.authorNavarro-Hernandez, R.E.
dc.contributor.authorOregon-Romero, E.
dc.contributor.authorRangel-Villalobos, H.
dc.contributor.authorVazquez-Del Mercado, M.
dc.contributor.authorRuiz-Quezada, S.L.
dc.contributor.authorMaldonado-Gonzalez, M.
dc.contributor.authorTorres-Vitela, R.
dc.contributor.authorMunoz-Valle, J.F.
dc.date.accessioned2015-09-15T18:55:47Z-
dc.date.available2015-09-15T18:55:47Z-
dc.date.issued2006
dc.identifier.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-33750013105&partnerID=40&md5=f219d3e4aa1945dce1a3931ea5fac34c
dc.identifier.urihttp://hdl.handle.net/20.500.12104/44502-
dc.description.abstractObjective. To investigate the relationship of A561C polymorphism and sE-selectin levels with rheumatoid arthritis (RA) clinical activity. Methods. In a case-control study, we compared 60 patients with RA and 60 healthy subjects. Patients fulfilled the 1987 American College of Rheumatology criteria. Soluble E-selectin levels were measured from serum samples using the ELISA kit. We investigated E-selectin A561C polymorphism by the restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR) technique. The disease activity was recorded with Spanish Health Assessment Questionnaire Disability Index (HAQ-DI), Spanish Arthritis Impact Measurement Scales (AIMS), and Disease Activity Score (DAS28) scores. A p value < 0.05 was considered significant. Results. Patients with RA showed higher sE-selectin levels than controls (mean 91.7 vs 39 ng/ml; p = 0.002). A positive correlation between sE-selectin and rheumatoid factor (RF), erythrocyte sedimentation rate (ESR). Spanish HAQ-DI. and DAS28 scores was found. The E-selectin polymorphism analysis showed diminished frequency in RA of heterozygous A/C genotype and increased frequency of homozygous wild-type A/A genotype (p = 0.043, OR 1.45: 95% CI 1.125-16.167) versus A/C and A/A genotype in healthy subjects. No significant association between A561C polymorphism and clinical activity was present. Conclusion. The sE-selectin, RF, and ESR, in addition to clinical indices, were associated with clinical activity in RA. We highlighted the presence of A/A genotype A561C polymorphism in our patients with RA.
dc.relation.isreferencedbyScopus
dc.relation.isreferencedbyWOS
dc.titlesE-selectin expression and A561C polymorphism in relation to rheumatoid arthritis clinical activity
dc.typeArticle
dc.relation.ispartofjournalJournal of Rheumatology
dc.relation.ispartofvolume33
dc.relation.ispartofissue10
dc.relation.ispartofpage1968
dc.relation.ispartofpage1972
dc.subject.keywordDisease activity score 28; Polymorphism; Rheumatoid arthritis; sE-selectin; Spanish health assessment questionnaire disability index; Spanish-arthritis impact measurement scales
dc.contributor.affiliationNavarro-Hern�ndez, R.E., Orientaci�n en Immunolog�a - Laboratorio de Immunolog�a, Instituto de Investigacion en Reumatologia y del Sistema Musculo Esqueletico, Departamento de Farmacobiolog�a, Jalisco, Mexico; Oreg�n-Romero, E., Orientaci�n en Immunolog�a - Laboratorio de Immunolog�a, Instituto de Investigacion en Reumatologia y del Sistema Musculo Esqueletico, Jalisco, Mexico; Rangel-Villalobos, H., Laboratorio de Gen�tica Molecular; V�zquez-Del Mercado, M., Orientaci�n en Immunolog�a - Laboratorio de Immunolog�a, Instituto de Investigacion en Reumatologia y del Sistema Musculo Esqueletico, Jalisco, Mexico; Ruiz-Quezada, S.L., Orientaci�n en Immunolog�a - Laboratorio de Immunolog�a, Instituto de Investigacion en Reumatologia y del Sistema Musculo Esqueletico, Jalisco, Mexico; Maldonado-Gonz�lez, M., Insituto de Investigacion en Reumatologia y del Sistema Musculo Esqueletico, Jalisco, Mexico; Torres-Vitela, R., Departamento de Farmacobiolog�a, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; Mu�oz-Valle, J.F., Orientaci�n en Immunolog�a - Laboratorio de Immunolog�a, Instituto de Investigacion en Reumatologia y del Sistema Musculo Esqueletico, Jalisco, Mexico, Instituto de Investigacion en Reumatologia y del Sistema Musculo Esqueletico, Centro Universitario de Ciencias de la Salud, Sierra Mojada Street No. 950, Guadalajara, Jalisco, C.P. 44281, Mexico
Appears in Collections:Producción científica UdeG

Files in This Item:
There are no files associated with this item.


Items in RIUdeG are protected by copyright, with all rights reserved, unless otherwise indicated.