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|Title:||Short-Term Effects on Substance Use of the Keeping It REAL Pilot Prevention Program: Linguistically Adapted for Youth in Jalisco, Mexico|
|Abstract:||Background/Aims: Alagille syndrome, a dominant inherited disorder, is characterized by cholestatic liver disease, associated to interlobular bile duct paucity combined with; cardiac, skeletal, ocular and facial abnormalities. Increased levels of serum lipids are present in more than 80% of probands. Parents and siblings of children with Alagille syndrome are often found to have a mild expression of this probable disease gene; it is not known if dyslipidemia occurs in parents and siblings of children with Alagille syndrome. The aim of the study was to investigate the lipid profile in sibs and parents of children with Alagille syndrome. Methodology: Four children with Alagille syndrome and 21 first-degree relatives were studied. Setting: A pediatric referral hospital. Period: July-October 2005. Design: cross-sectional. Variables: Total, low-density, high-density cholesterol and triglyceride. Statistics: ?2, Mann-Whitney U and Kruskal-Wallis. Results: Probands had higher levels of total cholesterol, low-density cholesterol and triglycerides than their siblings (p<0.05); however, no differences with their parents were observed (p>0.05). Conclusions: Dyslipidemia does not seem to be a phenotypic expression in first degree relatives of children with Alagille syndrome. The increased level of serum lipids observed in some of the parents is similar to the expected prevalence of hypercholesterolemia in the adult Mexican population. " H.G.E. Update Medical Publishing S.A.",,,,,,,,,"http://hdl.handle.net/20.500.12104/44499","http://www.scopus.com/inward/record.url?eid=2-s2.0-41549105363&partnerID=40&md5=47e0af19fa7fc383fc5cb74d60316182",,,,,,"81",,"Hepato-Gastroenterology",,"1|
WOS",,,,,,"Alagille syndrome; Serum lipids",,,,,,"Serum lipids in parents and siblings of children with Alagille syndrome: A pilot study",,"Article" "46309","123456789/35008",,"Marsiglia, F.F., School of Social Work, Southwest Interdisciplinary Research Center, Arizona State UniversityPhoenix, AZ, United States; Booth, J.M., School of Social Work, Southwest Interdisciplinary Research Center, Arizona State UniversityPhoenix, AZ, United States; Ayers, S.L., Southwest Interdisciplinary Research Center, Arizona State UniversityPhoenix, AZ, United States; Nuño-Gutierrez, B.L., University of Guadalajara and Mexican Social Security InstituteGuadalajara, Mexico; Kulis, S., Southwest Interdisciplinary Research Center, School of Social and Family Dynamics, Arizona State UniversityTempe, AZ, United States; Hoffman, S., School of Social Work, University of Texas at San AntonioSan Antonio, TX, United States",,"Marsiglia, F.F.
Hoffman, S.",,"2014",,"This article presents the short-term effects of a pilot study of keeping it REAL (Mantente REAL) conducted in central Mexico by a binational team of investigators. This middle school-based model program for preventing substance use was adapted for Mexico linguistically but not culturally. Two Guadalajara public middle schools were recruited and randomly assigned to either implement the prevention program or serve as a control site. The program was implemented in the treatment site by the studentsí regular teachers, who were trained by the research team. Seventh graders in ten classrooms in the treatment and control schools (N = 432) completed a pretest and posttest survey in Spanish similar to the survey utilized in the original efficacy trial of keeping it REAL in the US. T-tests and OLS regressions were conducted to determine the effects of the intervention on substance use outcomes. Differences between treatment and control groups in frequency of use of alcohol and tobacco, the two substances of choice in this sample, were significant and in the desired direction. Differences in amount of use were also in the preferred direction but were not significant for alcohol and only marginally significant for tobacco. When the sample was split by gender, statistically significant treatment effects remained for females but were not observed among males. Effects of the linguistically adapted version of keeping it REAL appears to be driven by the change in female use; however, the difference in male and female outcomes was not statistically significant. Implications for cultural adaptation and prevention in Mexico are discussed from a communication competency perspective. The promising results of the pilot study suggest that the linguistic adaptation was effective, but that a comprehensive cultural adaptation of keeping it REAL in partnership with Mexican investigators and communities may be warranted. " 2013, Society for Prevention Research.
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