Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/43938
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dc.contributor.authorSanchez-Hernandez, P.E.-
dc.contributor.authorRamirez-Duenas, M.G.-
dc.contributor.authorAlbarran-Somoza, B.-
dc.contributor.authorGarcia-Iglesias, T.-
dc.contributor.authordel Toro-Arreola, A.-
dc.contributor.authorFranco-Topete, R.-
dc.contributor.authorDaneri-Navarro, Adrián-
dc.date.accessioned2015-09-15T18:45:12Z-
dc.date.available2015-09-15T18:45:12Z-
dc.date.issued2008-
dc.identifier.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-37449024269&partnerID=40&md5=0fea950cd8466c50ed4d3b3f9c46e71c-
dc.identifier.urihttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med5&AN=17936340-
dc.identifier.urihttp://hdl.handle.net/20.500.12104/43938-
dc.description.abstractObjective.: Protease-activated receptor-2 (PAR-2) is a G-protein-coupled receptor that is cleaved and activated by trypsin and tryptase. There is evidence that PAR-2 contributes to tumor progression in stomach, colon, pancreas, prostate and breast cancer patients. However, the role of PAR-2 in cervical cancer is still unknown. The aim of this work was to study the PAR-2 expression in cervical cancer tissues and the effect of PAR-2 activation on cervical cancer proliferation. Methods.: Immunohistochemistry was used to analyze PAR-2 expression in fixed paraffin-embedded tumor tissue from 16 patients with invasive cervical cancer. HPV types were identified by PCR. PAR-2 expression in UISO-SQC-1, HeLa, SiHa, CasKi and C-33 A cervical cancer cell lines was evaluated by flow cytometry. Trypsin was detected by Western blot. Tumor proliferation in response to trypsin or agonist peptide was evaluated by the MTT method. Results.: A strong correlation between trypsin and PAR-2 expression in five cervical cancer cell lines, in association with proliferative growth in the presence of trypsin or agonist peptide, was found. All tumors from cervical cancer patients expressed PAR-2 (immunoreactive score was higher in poorly differentiated tumors). Conclusions.: Results suggest that trypsin and PAR-2 are involved in cervical cancer cell proliferation. © 2007 Elsevier Inc. All rights reserved.-
dc.relation.isreferencedbyScopus-
dc.relation.isreferencedbyMEDLINE-
dc.relation.isreferencedbyWOS-
dc.titleProtease-activated receptor-2 (PAR-2) in cervical cancer proliferation-
dc.typeArticle-
dc.identifier.doi10.1016/j.ygyno.2007.08.083-
dc.relation.ispartofjournalGynecologic Oncology-
dc.relation.ispartofvolume108-
dc.relation.ispartofissue1-
dc.relation.ispartofpage19-
dc.relation.ispartofpage26-
dc.subject.keywordCervical cancer and cellular proliferation; PAR-2; Trypsin-
dc.contributor.affiliationSánchez-Hernández, P.E., Departamento de Fisiología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada No 950, Colonia Independencia, Guadalajara, Jalisco, C.P. 44340, Mexico; Ramirez-Dueñas, M.G., Departamento de Fisiología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada No 950, Colonia Independencia, Guadalajara, Jalisco, C.P. 44340, Mexico; Albarran-Somoza, B., Facultad de Farmacia y Bioanálisis, Universidad de los Andes, Merida, Venezuela; García-Iglesias, T., Departamento de Fisiología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada No 950, Colonia Independencia, Guadalajara, Jalisco, C.P. 44340, Mexico; del Toro-Arreola, A., Departamento de Fisiología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada No 950, Colonia Independencia, Guadalajara, Jalisco, C.P. 44340, Mexico; Franco-Topete, R., Servicio de Patología, OPD Hospital Civil de Guadalajara, Mexico; Daneri-Navarro, A., Departamento de Fisiología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada No 950, Colonia Independencia, Guadalajara, Jalisco, C.P. 44340, Mexico-
dc.subject.headingIndex Medicus;Alphapapillomavirus/ge [Genetics];Carcinoma, Squamous Cell/me [Metabolism];Carcinoma, Squamous Cell/pa [Pathology];Carcinoma, Squamous Cell/vi [Virology];Cell Growth Processes/de [Drug Effects];Cell Growth Processes/ph [Physiology];Cell Line, Tumor;Female;Flow Cytometry;HeLa Cells;Humans;Immunohistochemistry;Neoplasm Staging;Papillomavirus Infections/me [Metabolism];Papillomavirus Infections/pa [Pathology];Paraffin Embedding;Polymerase Chain Reaction;Receptor, PAR-2/bi [Biosynthesis];Trypsin/bi [Biosynthesis];Trypsin/pd [Pharmacology];Uterine Cervical Neoplasms/me [Metabolism];Uterine Cervical Neoplasms/pa [Pathology];Uterine Cervical Neoplasms/vi [Virology]-
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