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Title: Proinflammatory cytokines and apoptosis following glutamate-induced excitotoxicity mediated by p38 MAPK in the hippocampus of neonatal rats
Author: Chaparro-Huerta, V.
Rivera-Cervantes, M.C.
Flores-Soto, M.E.
Gomez-Pinedo, U.
Beas-Zárate, Carlos
Issue Date: 2005
Abstract: The proinflammatory cytokines TNF-?, IL-1?, and IL-6 rise during neuronal damage and activate the apoptotic mitogen-activated protein kinase p38. We studied apoptosis, the levels of TNF-?, IL-1?, and IL-6, and the cell type producing TNF-? in rats at 8, 10, and 14 days of age after neonatal exposure to glutamate, which induces neuronal damage. TNF-? production was significantly increased by glutamate, but inhibited by SB203580 (a p38 inhibitor). TNF-?, IL-1?, and IL-6 mRNA levels increased, but SB203580 did not modify their expression. Thus, the p38 signaling pathway influences the expression of inflammatory genes and its inhibition may offer anti-inflammatory therapy. © 2005 Elsevier B.V. All rights reserved.
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