Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/43825
Title: Prescribing pattern of glucose lowering drugs in the United Kingdom in the last decade: A focus on the effects of safety warnings about rosiglitazone
Author: Reyes-Lozano, C.A.
Gudino, P.O.
Gonzalez-Nunez, R.
Rodrigue, D.
Issue Date: 2011
Abstract: In this work, preparation and characterization of HDPE/PA6 foam blends is presented. Using a chemical blowing agent based on azodicarbonamide, foams were produced via extrusion using different concentrations of the dispersed phase PA6. Due to very different thermal and rheological properties of the polymers, good cellular structures could only be obtained by a careful selection of the temperature profile and feeding strategy of the materials. Furthermore, the use of a coupling agent was also found necessary to stabilize the blend before foaming. The final foam morphology was controlled by post-extrusion conditions and the results are discussed in terms of deformation and dimensions of foam cells and dispersed phase particles. The tensile and impact properties of the resulting foams are also reported. " The Author(s) 2010.",,,,,,"10.1177/0021955X10394545",,,"http://hdl.handle.net/20.500.12104/43825","http://www.scopus.com/inward/record.url?eid=2-s2.0-79953898863&partnerID=40&md5=1637047e9a167a3db62040789cf1fcaf",,,,,,"2",,"Journal of Cellular Plastics",,"153
172",,"47",,"Scopus
WOS",,,,,,"Blend; Foam; High density polyethylene; Polyamide",,,,,,"Preparation and characterization of HDPE/PA6 foam blends",,"Article" "45610","123456789/35008",,"Leal, I., Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, Netherlands, Department of Physiology, University of Guadalajara, Guadalajara, Mexico; Romio, S.A., Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, Netherlands; Schuemie, M., Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, Netherlands; Oteri, A., Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, Netherlands; Sturkenboom, M., Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, Netherlands; Trifiró, G., Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, Netherlands, Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Messina, Italy",,"Leal, I.
Romio, S.A.
Schuemie, M.
Oteri, A.
Sturkenboom, M.
Trifiro, G.",,"2013",,"Aim: In the last decade, new glucose lowering drugs (GLDs) have been launched, and also several warnings regarding their safety. The cardiovascular safety of thiazolidinediones (TZD) has been questioned. We analyzed the prescription pattern of GLDs from 2000 to November 2009 in the United Kingdom (UK) using the THIN database with special focus on the effects of the safety warnings about rosiglitazone issued in May 2007 and January 2008. Methods: Annual prevalence and incidence of GLD prescriptions were measured. For TZD, the monthly prevalence and incidence of prescription were calculated from May 2006 to January 2009. The switching pattern around the FDA alert and the characteristics of subjects starting treatment with TZD before and after the alerts were observed. Results: The prevalence of prescriptions of GLDs increased during the 10year period, metformin increasing more than three times. Rosiglitazone prevalence showed an increased trend until May 2007, (2.3/1000 person-years) and decreased thereafter (January 2009: 1.1/1000 person-years). The use of pioglitazone increased surpassing rosiglitazone from April 2008 onwards. The incidence of rosiglitazone use decreased sharply after May 2007 (0.8/1000 person-years). The prevalence of use of other therapies remained rather stable from 2000 to 2007 but increased afterwards. After May 2007, rosiglitazone users were increasingly switched to pioglitazone. There was an increased proportion of new users of pioglitazone with cardiovascular risk after the alerts. Conclusions: The prescription of GLDs in the UK has increased in the last decade. For TZDs, it changed after May 2007 as well as the characteristics of the subjects treated with them. " 2012 The British Pharmacological Society.
URI: http://hdl.handle.net/20.500.12104/43831
http://www.scopus.com/inward/record.url?eid=2-s2.0-84873419516&partnerID=40&md5=ec822f1642e17786a81f6761167ea8e0
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