Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/43809
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dc.contributor.authorSoria-Fregozo, C.-
dc.contributor.authorPerez-Vega, M.I.-
dc.contributor.authorGonzalez-Burgos, I.-
dc.contributor.authorFeria-Velasco, A.-
dc.contributor.authorBeas-Zárate, Carlos-
dc.date.accessioned2015-09-15T18:42:33Z-
dc.date.available2015-09-15T18:42:33Z-
dc.date.issued2008-
dc.identifier.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-52549129092&partnerID=40&md5=504d51e31a196eedcefbfd1ea3005c07-
dc.identifier.urihttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med5&AN=18496752-
dc.identifier.urihttp://hdl.handle.net/20.500.12104/43809-
dc.description.abstractThe 5-HTergic system and particularly 5-HT2A receptors have been involved in prefrontal cognitive functions, but the underlying mechanisms by which the serotonin (5-HT) system modulates these processes are still unclear. In this work, the effects of prefrontal 5-HTergic denervation on the density and expression levels of 5-HT2A receptors were evaluated by immunohistochemical and molecular biology studies in the prefrontal cortex (PFC). The [3H]-Ketanserin binding study revealed an increase in the Bmax, along with no change in the binding affinity (KD) for 5-HT2A receptors. The increase in PFC of 5-HT2A receptor density in response to denervation was accompanied by increase in 5-HT2A receptor mRNA and protein levels. This increase in the number of 5-HT2A receptors may be interpreted as an adaptive plastic change, i.e., hypersensitivity; resulting from the selective pharmacological lesion of the raphe-proceeding 5-HTergic fibers to the PFC. Based on previous evidence, this could be strongly related to the abnormal expression of short-term memory. © 2008 Springer Science+Business Media, LLC.-
dc.relation.isreferencedbyScopus-
dc.relation.isreferencedbyMEDLINE-
dc.relation.isreferencedbyWOS-
dc.titlePrefrontal serotonergic denervation induces increase in the density of 5-HT2A receptors in adult rat prefrontal cortex-
dc.typeArticle-
dc.identifier.doi10.1007/s11064-008-9740-7-
dc.relation.ispartofjournalNeurochemical Research-
dc.relation.ispartofvolume33-
dc.relation.ispartofissue11-
dc.relation.ispartofpage2350-
dc.relation.ispartofpage2357-
dc.subject.keyword5,7-DHT; 5-HT2A receptor; Prefrontal cortex; Serotonin; Short-term memory-
dc.contributor.affiliationSoria-Fregozo, C., Laboratorio de Psicobiología, Centro Universitario de Los Lagos, Universidad de Guadalajara (U. de G.), Lagos de Moreno, Jalisco, Mexico; Pérez-Vega, M.I., Laboratorio de Psicobiología, Centro Universitario de Los Lagos, Universidad de Guadalajara (U. de G.), Lagos de Moreno, Jalisco, Mexico; González-Burgos, I., Div. de Neurociencias, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social (IMSS), Sierra Mojada# 800, Col. Independencia, Guadalajara, Jalisco 44340, Mexico, Laboratorio de Neurobiología Celular, Departamento de Biología Celular Y Molecular, CUCBA, U. de G., Zapopan, Jalisco, Mexico; Feria-Velasco, A., Laboratorio de Neurobiología Celular, Departamento de Biología Celular Y Molecular, CUCBA, U. de G., Zapopan, Jalisco, Mexico; Beas-Zárate, C., Div. de Neurociencias, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social (IMSS), Sierra Mojada# 800, Col. Independencia, Guadalajara, Jalisco 44340, Mexico, Laboratorio de Desarrollo Y Regeneración Neuronal, Departamento de Biología Celular Y Molecular, CUCBA, U. de G., Zapopan, Jalisco, Mexico-
dc.contributor.affiliationBeas-Zárate, Carlos., Universidad de Guadalajara. Centro Universitario de Ciencias Biológicas y Agropecuarias-
dc.subject.headingIndex Medicus;Animals;Base Sequence;Blotting, Western;Chromatography, High Pressure Liquid;DNA Primers;Denervation;Female;Frontal Lobe/me [Metabolism];Immunohistochemistry;Rats;Rats, Sprague-Dawley;Receptor, Serotonin, 5-HT2A/me [Metabolism];Serotonin/me [Metabolism]-
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