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|Title:||Polymorphisms of the XRCC1 gene and breast cancer risk in the Mexican population|
Vazquez Del Mercado, M.
|Abstract:||Rheumatoid arthritis (RA) is the prototype of the rheumatic diseases worldwide. Methotrexate (MTX) is the drug of first choice in the treatment of this disease due to its immunosuppressant effect. However, side events are present in 30% of the patients. The C677T and A1298C polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) gene are involved in the metabolism of MTX. Earlier studies reported an association between these polymorphisms and elevation of hepatic enzymes. We analyzed the frequencies of both polymorphisms and the presence of transaminasemia in 70 Mexican patients with rheumatic arthritis treated with MTX. The 19% (13/70) of patients had an increase in the serum level of transaminases. The A1298C polymorphism was associated with elevation of transaminases (P0.024). The identification of MTHFR genotypes for C677T and A1298C polymorphisms could lead clinicians to identify patients in risk of elevation of transaminases, and give them an individualized treatment, as is a goal of pharmacogenetics. " 2011 Macmillan Publishers Limited. All rights reserved.",,,,,,"10.1038/tpj.2010.32",,,"http://hdl.handle.net/20.500.12104/43723","http://www.scopus.com/inward/record.url?eid=2-s2.0-79960646716&partnerID=40&md5=576ca7a7fb62b61e500a0fd8d3405114|
WOS",,,,"Index Medicus;Antirheumatic Agents/ae [Adverse Effects];Antirheumatic Agents/pk [Pharmacokinetics];Arthritis, Rheumatoid/dt [Drug Therapy];Arthritis, Rheumatoid/en [Enzymology];Arthritis, Rheumatoid/eh [Ethnology];Arthritis, Rheumatoid/ge [Genetics];Case-Control Studies;Chi-Square Distribution;Gene Frequency;Genotype;Humans;Individualized Medicine;Methotrexate/ae [Adverse Effects];Methotrexate/pk [Pharmacokinetics];Methylenetetrahydrofolate Reductase (NADPH2)/ge [Genetics];Methylenetetrahydrofolate Reductase (NADPH2)/me [Metabolism];Mexico/ep [Epidemiology];Odds Ratio;Pharmacogenetics;Phenotype;Polymorphism, Genetic;Risk Assessment;Risk Factors;Transaminases/bl [Blood];Treatment Outcome;Up-Regulation",,"methotrexate; MTHFR; pharmacogenetics; rheumatoid arthritis; transaminases",,,,,,"Polymorphisms C677T and A1298C in the MTHFR gene in Mexican patients with rheumatoid arthritis treated with methotrexate: Implication with elevation of transaminases",,"Article" "45508","123456789/35008",,"Macías-Gómez, N.M., Departamento de Salud y Bienestar del Centro Universitario del Sur, Universidad de GuadalajaraCd. Guzmán, Jal., Mexico; Peralta-Leal, V., Facultad de Medicina e Ingeniería en Sistemas Computacionales de Matamoros, Universidad Autónoma de Tamaulipas, Sendero Nacional km 3Matamoros, Tamaulipas, Mexico; Meza-Espinoza, J.P., Facultad de Medicina e Ingeniería en Sistemas Computacionales de Matamoros, Universidad Autónoma de Tamaulipas, Sendero Nacional km 3Matamoros, Tamaulipas, Mexico; Gutiérrez-Angulo, M., Centro Universitario de los Altos, Universidad de GuadalajaraTepatitlán de Morelos, Jal., Mexico; Durán-González, J., Facultad de Medicina e Ingeniería en Sistemas Computacionales de Matamoros, Universidad Autónoma de Tamaulipas, Sendero Nacional km 3Matamoros, Tamaulipas, Mexico, University of Texas at BrownsvilleBrownsville, TX, United States; Ramírez-González, J.M., Facultad de Medicina e Ingeniería en Sistemas Computacionales de Matamoros, Universidad Autónoma de Tamaulipas, Sendero Nacional km 3Matamoros, Tamaulipas, Mexico; Gaspar-Del Toro, A., Departamento de Salud y Bienestar del Centro Universitario del Sur, Universidad de GuadalajaraCd. Guzmán, Jal., Mexico; Norberto-Rodríguez, A., Hospital General "Alfredo Pumarejo" Matamoros, Tamps., Mexico; Leal-Ugarte, E., Facultad de Medicina e Ingeniería en Sistemas Computacionales de Matamoros, Universidad Autónoma de Tamaulipas, Sendero Nacional km 3Matamoros, Tamaulipas, Mexico",,"Macias-Gomez, N.M.
Gaspar-Del Toro, A.
Leal-Ugarte, E.",,"2015",,"The purpose of this case-control study was to evaluate the association of XRCC1 Arg194Trp and Arg399Gln polymorphisms with susceptibility to breast cancer (BC) in a Mexican population. We analysed DNA samples from 345 BC patients and 352 control subjects by polymerase chain reaction-restriction fragment length polymorphism. The frequency of the 399Gln allele was 23 % in controls and 29 % in patients [OR 1.38 (1.08 1.76); p = 0.01]; genotypes in controls were 60, 36, and 4 % for Arg/Arg, Arg/Gln, and Gln/Gln, respectively, while in patients they were 53, 36, and 11 % [OR 2.71 (1.44 5.10); p = 0.0015 for the Gln/Gln genotype]. Regarding the Arg194Trp polymorphism, the frequency of Trp allele was 15 % in controls and 16 % in patients [OR 1.09 (0.82 1.46); p = 0.54]; the genotype frequencies in controls were 74, 23, and 3 % for Arg/Arg, Arg/Trp and Trp/Trp, respectively, while in patients these were 73, 23, and 4 % [OR 1.41 (0.64 3.14); p = 0.39 for the Trp/Trp genotype]. Allele frequencies were consistent with Hardy Weinberg equilibrium (p = 0.20 for Arg194Trp and p = 0.54 for Arg399Gln). Our results indicate that the 399Gln polymorphism is associated with an increased risk of BC. Additionally, we found that some covariates increase the risk of BC in Mexican women; namely, antecedent of abortions [OR 3.69 (2.17 6.27); p < 0.001], not breastfeeding [OR 2.46 (1.45 4.18); p = 0.001], family history of BC [OR 15.9 (5.09 50.23); p < 0.001], other type of family cancer [OR 31.5 (12.5 79.3); p < 0.001], alcoholism [OR 17.7 (5.2 60.42); p < 0.001], type 2 diabetes mellitus [OR 2.28 (1.26 4.10); p = 0.007], and contraceptive use [OR 2.28 (1.26 4.10); p < 0.001]. " 2015 Springer Science+Business Media Dordrecht
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