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Title: PI controller design for a class of distributed parameter systems
Author: Velazquez-Zamora, D.A.
Gonzalez-Tapia, D.
Gonzalez-Ramirez, M.M.
Flores-Soto, M.E.
Vazquez-Valls, E.
Cervantes, M.
Gonzalez-Burgos, I.
Issue Date: 2012
Abstract: Cognitive impairment or its recovery has been associated with the absence or reestablishment of estrogenic actions in the central nervous system of female experimental animals or women. It has been proposed that these cognitive phenomena are related to estrogen-mediated modulatory activity of synaptic transmission in brain structures involved in cognitive functions. In the present work a morphological study was conducted in adult female ovariectomized rats to evaluate estradiol-dependent dendritic spine sprouting in hippocampal pyramidal neurons, and changes in the presynaptic marker synaptophysin. Three or ten days after estradiol treatment (10 ?g/day, twice) in the ovariectomized rats, a significant increase of synaptophysin was observed, which was coincident with a significant higher numerical density of thin (22%), stubby (36%), mushroom (47%) and double spines (125%), at day 3, without significant changes of spine density at day 10, after treatment. These results may be interpreted as evidence of pre- and postsynaptic plastic events that may be involved in the modulation of cognitive-related behavioral performance after estrogen replacement therapy. " 2012 Elsevier B.V. Al l rights reserved.",,,,,,"10.1016/j.brainres.2012.06.012",,,"","",,,,,,,,"Brain Research",,"1
WOS",,,,,,"CA1; Dendritic spine; Estrogen; Hippocampus; Plasticity; Synaptophysin",,,,,,"Plastic changes in dendritic spines of hippocampal CA1 pyramidal neurons from ovariectomized rats after estradiol treatment",,"Article" "45403","123456789/35008",,"Aguilar-Garnica, E., Departamento de Química, Universidad Autónoma de Guadalajara, Av. Patria 1201, Guadalajara, Jalisco 44100, Mexico; García-Sandoval, J.P., Departamento de Ingeniería Química, Universidad de Guadalajara, Calz. Gral. Marcelino García Barragán 1451, Guadalajara, Jalisco 44430, Mexico; González-Álvarez, V., Departamento de Ingeniería Química, Universidad de Guadalajara, Calz. Gral. Marcelino García Barragán 1451, Guadalajara, Jalisco 44430, Mexico",,"Aguilar-Garnica, E.
García-Sandoval, J.P.
Gonzalez-Alvarez, V.",,"2011",,"In this paper, the regulation problem of convection governed dynamical processes described by linear distributed parameter models with position-independent inputs is addressed by combining the method of characteristics (MC) and the Malek-Zavarei and Jamshidi theorem. In this approach, the MC is used to transform the first order partial differential equations model of such processes into a set of time-delayed ordinary differential equations whose elements are used to generate certain matrices that satisfy linear matrix inequalities that render the proportional integral (PI) control parameters that guarantee the process stability. The performance of the proposed PI controller is tested via numerical simulations in the temperature regulation of a linear heat exchanger and compared to a tightly tuned classical PI controller. The application of the proposed controller is extended to regulate the outlet concentration in a nonlinear non-isothermal plug flow reactor. It is shown that the proposed controller is able to handle the infinite dimensional nature of the process model yielding smooth and unsaturated responses around the predetermined set-point trajectory in the face of load changes, time varying boundary conditions and set-point changes. " 2011 Elsevier Ltd.
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