Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/43635
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dc.contributor.authorCastro-Torres, R.D.-
dc.contributor.authorChaparro-Huerta, V.-
dc.contributor.authorFlores-Soto, M.E.-
dc.contributor.authorJave-Suarez, L.-
dc.contributor.authorCamins, A.-
dc.contributor.authorArmendariz-Borunda, J.-
dc.contributor.authorBeas-Zárate, Carlos-
dc.contributor.authorMena-Munguia, S.-
dc.date.accessioned2015-09-15T18:39:09Z-
dc.date.available2015-09-15T18:39:09Z-
dc.date.issued2015-
dc.identifier.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-84923035820&partnerID=40&md5=0ca78a0be9e4e12fd95bfdec3a065280-
dc.identifier.urihttp://hdl.handle.net/20.500.12104/43635-
dc.description.abstractExcitotoxicity and neuroinflammation are strongly linked to the progressions of neurodegenerative diseases and acute injuries in the brain. Systematic administration of kainic acid (KA) in rodents causes severe limbic seizures, selective neuronal loss, and neuroinflammation in the hippocampus that are attributed to the excitotoxic process. Our previous report demonstrated the antioxidant and neuroprotective effects of pirfenidone (PFD) after the seizure onset induced by KA intraperitoneal injection. However, the aim of the present study is to analyze whether PFD has anti-inflammatory properties. Thus, pubescent male Wistar rats (30 days old) were exposed to 12 mg/Kg of KA, and the experimental group received KA and a single dose of 325 mg/Kg PFD in an orogastric tube at 90 min after KA exposure. The PFD treatment dramatically reduces the microglial activation observed by isolectin B4 staining and major histocompatibility complex II immunohistochemistry. We also determined that the messenger RNA of inducible nitric oxide synthase was downregulated by PFD treatment as measured 6 h after the KA injection. Our results indicate that the mechanism of neuroprotection after PFD treatment may include a decreased expression of the inducible nitric oxide synthase and reduced microglial activation. These findings suggest that PFD is a potentially useful strategy of the treatment for acute or chronic neurodegenerative diseases. © 2015 Springer Science+Business Media New York-
dc.relation.isreferencedbyScopus-
dc.titlePirfenidone Attenuates Microglial Reactivity and Reduces Inducible Nitric Oxide Synthase mRNA Expression After Kainic Acid-Mediated Excitotoxicity in Pubescent Rat Hippocampus-
dc.typeArticle in Press-
dc.identifier.doi10.1007/s12031-015-0509-6-
dc.relation.ispartofjournalJournal of Molecular Neuroscience-
dc.subject.keywordCytokines; iNOS; Kainic acid; Microglial reactivity; Pirfenidone-
dc.contributor.affiliationCastro-Torres, R.D., Laboratorio de Neurobiología Celular y Molecular, Centro de Investigación Biomédica de Occidente (CIBO)Guadalajara, Jalisco, Mexico; Chaparro-Huerta, V., Laboratorio de Neurobiología Celular y Molecular, Centro de Investigación Biomédica de Occidente (CIBO)Guadalajara, Jalisco, Mexico; Flores-Soto, M.E., Laboratorio de Neurobiología Celular y Molecular, Centro de Investigación Biomédica de Occidente (CIBO)Guadalajara, Jalisco, Mexico; Jave-Suárez, L., División de Inmunología, Centro de Investigación Biomédica de Occidente, IMSSGuadalajara, Jalisco, Mexico; Camins, A., Unitat de Farcalogia i Farmacognosia, Facultat de Farmacia, Centros de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Instituto de Biomedicina (IBUB), Universitat de Barcelona, Nuclei Universtari de PedralbesBarcelona, Spain; Armendáriz-Borunda, J., Instituto de Biología Molecular en Medicina y Terapia Génica, CUCS, Departamento de Biología Molecular y Genómica, CUCS, Universidad de GuadalajaraGuadalajara, Jalisco, Mexico, INNOVAREGuadalajara, Jalisco, Mexico; Beas-Zárate, C., Laboratorio de Neurobiología Celular y Molecular, Centro de Investigación Biomédica de Occidente (CIBO)Guadalajara, Jalisco, Mexico, Laboratorio de Desarrollo y Regeneración Neural, Departamento de Biología Celular y Molecular, CUCBA, Universidad de GuadalajaraGuadalajara, Jalisco, Mexico; Mena-Munguía, S., IMAREFI, Departamento de Producción Agrícola, Division de Ciencias Agronómicas, CUCBA, Universidad de Guadalajara, Km. 15.5 Carr GDL-Nogales, NextipacZapopan, Jalisco, Mexico-
dc.contributor.affiliationBeas-Zárate, Carlos., Universidad de Guadalajara. Centro Universitario de Ciencias Biológicas y Agropecuarias-
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