Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/43540
Title: Pesticide toxicity and its association with Parkinson's disease [Toxicidad de plaguicidas y su asociación con la enfermedad de Parkinson]
Author: Ringman, J.M.
Rodriguez, Y.
Diaz-Olavarrieta, C.
Chavez, M.
Thompson, M.
Fairbanks, L.
Paz, F.
Varpetian, A.
Chaparro, H.
Macias-Islas, M.A.
Murrell, J.
Ghetti, B.
Kawas, C.
Issue Date: 2007
Abstract: Background: Spanish-language screening tests that are sensitive to the early cognitive changes of Alzheimer's disease (AD) are needed. Persons known to be at 50% risk for young-onset AD due to presenilin-1 (PSEN1) mutations provide the opportunity to assess which measures on the Mini-mental State Examination (MMSE) are most sensitive to these early changes. Methods: We performed genetic and Spanish-language cognitive testing on 50 Mexican persons without dementia at risk for inheriting PSEN1 mutations. We then compared the performance on sub-items of the MMSE between PSEN1 mutation carriers (MCs) and non-carriers (NCs) using t-tests and Fisher's exact tests. Exploratory multiple logistic regression analyses were also performed. Results: Twenty-nine persons were MCs and 21 NCs. NCs tended to achieve higher levels of education (p = 0.039) than did MCs. MCs tended to perform more poorly when spelling "MUNDO" backwards and on Orientation, particularly regarding the date. In multiple regression analyses the ability of backwards spelling to predict PSEN1 mutation status was reduced when education was included as an independent variable. Conclusion: Subjects in the earliest stage of PSEN1-related AD showed deficits on orientation to date and in divided attention when spelling backwards. It is unclear if educational level should be considered an associated feature or a con-founding variable in this population although it should be taken into account when considering performance on the MMSE task of divided attention. The relative lack of deficits on delayed recall of three words probably represents the insensitivity of this measure in early AD. This study supports the utility of autosomal dominant AD as a model of the more common sporadic form of the disorder. " 2006 International Psychogeriatric Association.",,,,,,"10.1017/S1041610206003772",,,"http://hdl.handle.net/20.500.12104/43540","http://www.scopus.com/inward/record.url?eid=2-s2.0-33847770795&partnerID=40&md5=4de67b9f2c18c2772ad3c72f6d24ce2b",,,,,,"2",,"International Psychogeriatrics",,"323
332",,"19",,"Scopus
WOS",,,,,,"Alzheimer's disease; Cognition; Education; Mini-mental State Examination; Preclinical; Presenilin; Screening test; Spanish",,,,,,"Performance on MMSE sub-items and education level in presenilin-1 mutation carriers without dementia",,"Article" "45327","123456789/35008",,"Ortiz, G.G., Laboratorio de Estrés Oxidativo y Patología, División de Neurociencias, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, Mexico, División Ciencias de la Salud, Escuela de Medicina, Instituto Tecnológico y de Estudios Superiores de Monterrey, Campus Guadalajara, Zapopan, Jalisco, Mexico; Moisés, F.P.P., Departamento de Química, Centro Universitario de Ciencias Exactas e Ingenierías, Universidad de Guadalajara, Blvd. Marcelino García Barragán # 1421, Guadalajara, Jalisco, Mexico; Macías-Islas, M.A., Departamento de Neurología, UMAE-Hospital de Especialidades, Centro Médico Nacional de Occidente-IMSS, Guadalajara, Jalisco, Mexico; Jiménez-Gil, F.J., Departamento de Neurología, UMAE-Hospital de Especialidades, Centro Médico Nacional de Occidente-IMSS, Guadalajara, Jalisco, Mexico; Miranda-Díaz, A.G., Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; Flores-Alvarado, L.J., Departamento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; Cruz-Rámos, J.A., Laboratorio de Estrés Oxidativo y Patología, División de Neurociencias, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, Mexico; Morales-Sánchez, E.W., Laboratorio de Estrés Oxidativo y Patología, División de Neurociencias, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, Mexico; Ramírez-Ramírez, V., Laboratorio de Estrés Oxidativo y Patología, División de Neurociencias, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, Mexico; Alatorre-Jiménez, M., Laboratorio de Estrés Oxidativo y Patología, División de Neurociencias, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, Mexico; Bitzer-Quintero, O.K., Laboratorio de Neuroinmunomodulación, División de Neurociencias, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, Mexico",,"Ortiz, G.G.
Moises, F.P.P.
Macias-Islas, M.A.
Jimenez-Gil, F.J.
Miranda-Diaz, A.G.
Flores-Alvarado, L.J.
Cruz-Ramos, J.A.
Morales-Sanchez, E.W.
Ramirez-Ramirez, V.
Alatorre-Jimenez, M.
Bitzer-Quintero, O.K.",,"2011",,"Epidemiological data in humans and studies in animal models of Parkinson's disease (PD) suggest that sporadic forms of the disorder are not strictly genetic in nature but most likely because of combined environmental exposures over the period of the life-span coupled with increased genetic susceptibilities. Exposure to agricultural chemicals such as paraquat, diquat, maneb, rotenone, and dieldrin has been separately suggested as potential risk factors for sporadic forms of the disease. In addition, exposure to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a by-product of synthetic heroine causes a clinical condition almost identical to PD. Interestingly, paraquat and MPTP share striking structural similarities. There is a growing consensus that oxidative stress and inflammation plays a key role in PD. Using a rodent model we found that melatonin attenuates the increases in lipid peroxidation products, nitric oxide catabolites and ciclooxygenase 2 activity elicited by MPTP injection. These data suggest that neuroprotective effects of melatonine are partly attributed to its antioxidant and anti-inflammatory action. Copyright " Indice Mexicano de Revistas Biomédicas Latinoamericanas 1998 - 2013.
URI: http://hdl.handle.net/20.500.12104/43548
http://www.scopus.com/inward/record.url?eid=2-s2.0-84887467515&partnerID=40&md5=2a85cfad81c5039b1546978f4841f23b
Appears in Collections:Producción científica UdeG

Files in This Item:
There are no files associated with this item.


Items in RIUdeG are protected by copyright, with all rights reserved, unless otherwise indicated.