Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/43451
Title: Interval-Based Diagnosis of Biological Systems - a Powerful Tool for Highly Uncertain Anaerobic Digestion Processes
Author: Rodriguez-Carrizalez, A.D.
Castellanos-Gonzalez, J.A.
Martinez-Romero, E.C.
Miller-Arrevillaga, G.
Villa-Hernandez, D.
Hernandez-Godinez, P.P.
Ortiz, G.G.
Pacheco-Moises, F.P.
Cardona-Munoz, E.G.
Miranda-Diaz, A.G.
Issue Date: 2014
Abstract: Background: Diabetic retinopathy (DR) is a preventable cause of visual disability. The aims of the present study were to investigate levels and behavior oxidative stress markers and mitochondrial function in non-proliferative DR (NPDR) and to establish the correlation between the severity of NPDR and markers of oxidative stress and mitochondrial function. Methods: In a transverse analysis, type 2 diabetes mellitus (T2DM) patients with mild, moderate and severe non-proliferative DR (NPDR) were evaluated for markers of oxidative stress (i.e. products of lipid peroxidation (LPO) and nitric oxide (NO) catabolites) and antioxidant activity (i.e. total antioxidant capacity (TAC), catalase, and glutathione peroxidase (GPx) activity of erythrocytes). Mitochondrial function was also determined as the fluidity of the submitochondrial particles of platelets and the hydrolytic activity of F0/F1-ATPase. Results: Levels of LPO and NO were significantly increased in T2DM patients with severe NPDR (3.19 0.05?mol/mL and 45.62 1.27pmol/mL, respectively; P<0.007 and P<0.0001 vs levels in health volunteers, respectively), suggesting the presence of oxidative stress. TAC had significant decrease levels with minimum peak in severe retinopathy with 7.98 0.48mEq/mL (P<0.0001). In contrast with TAC, erythrocyte catalase and GPx activity was increased in patients with severe NPDR (139.4 4.4 and 117.13 14.84U/mg, respectively; P<0.0001 vs healthy volunteers for both), suggesting an imbalance between oxidants and antioxidants. The fluidity of membrane submitochondrial particles decreased significantly in T2DM patients with mild, moderate, or severe NPDR compared with that in healthy volunteers (P<0.0001 for all). Furthermore, there was a significant increase in the hydrolytic activity of the F0/F1-ATPase in T2DM patients with mild NPDR (265.07 29.55nmol/PO4; P<0.0001 vs healthy volunteers), suggesting increased catabolism. Conclusions: Patients with NPDR exhibit oxidative deregulation with decreased membrane fluidity of submitochondrial particles and increased systemic catabolism (mitochondrial dysfunction) with the potential for generalized systemic damage in T2DM. " 2013 The Authors. Journal of Diabetes published by Ruijin Hospital, Shanghai Jiaotong University School of Medicine and Wiley Publishing Asia Pty Ltd.",,,,,,"10.1111/1753-0407.12076",,,"http://hdl.handle.net/20.500.12104/43451","http://www.scopus.com/inward/record.url?eid=2-s2.0-84895071252&partnerID=40&md5=d3b0033aa6faf6f6a5e209b1a8f72b89
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=23875878",,,,,,"2",,"Journal of Diabetes",,"167
175",,"6",,"Scopus
MEDLINE
WOS",,,,"Index Medicus;Adenosine Triphosphate/me [Metabolism];Adult;Aged;Antioxidants/me [Metabolism];Catalase/me [Metabolism];Diabetes Mellitus, Type 2/bl [Blood];Diabetes Mellitus, Type 2/co [Complications];Diabetes Mellitus, Type 2/me [Metabolism];Diabetic Retinopathy/bl [Blood];Diabetic Retinopathy/et [Etiology];Diabetic Retinopathy/me [Metabolism];Erythrocytes/me [Metabolism];Female;Glutathione Peroxidase/me [Metabolism];Humans;Hydrolysis;Lipid Peroxidation;Male;Membrane Fluidity;Middle Aged;Mitochondria/me [Metabolism];Mitochondria/ph [Physiology];Mitochondrial Membranes/ch [Chemistry];Mitochondrial Membranes/me [Metabolism];Multivariate Analysis;Nitric Oxide/me [Metabolism];Oxidants/me [Metabolism];Proton-Translocating ATPases/me [Metabolism]",,"Diabetes mellitus; Diabetic retinopathy; Membrane fluidity; Nitrosative stress; Oxidative",,,,,,"Oxidants, antioxidants and mitochondrial function in non-proliferative diabetic retinopathy",,"Article" "44061","123456789/35008",,,,"Aguiar Barrera, Martha Elena",,"2011",,"En este artículo se investiga el rendimiento académico de las mujeres en matemáticas en los niveles preuniversitario y universitario. El estudio consta de dos partes; en la primera, se indaga en la literatura los reportes sobre dicho rendimiento en la etapa preuniversitaria en América Latina, con énfasis en México, y se concluye que en términos generales los puntajes promedio obtenidos por las mujeres son menores de los obtenidos por los hombres, y esto contribuye, entre otras cosas, a que una menor cantidad de mujeres opten por carreras universitarias científico-tecnológicas. En la segunda parte, se investiga el rendimiento en matemáticas de las mujeres en nivel superior; se hace un análisis estadístico de su rendimiento en un medio masculinizado, como lo es el Centro Universitario de Ciencias Exactas e Ingenierías (CUCEI) de la Universidad de Guadalajara. Se utilizan los datos de evaluaciones estandarizadas y continuas de los estudiantes en las materias de matemáticas del CUCEI; y se encuentra que las alumnas obtienen en promedio mejores resultados que los alumnos. Además se deduce que las profesoras tienen mejor desempeño, en el sentido de que sus estudiantes, de ambos sexos, superan en su puntaje promedio a los estudiantes de los profesores varones.",,,,,,,,"1409-4703","http://hdl.handle.net/20.500.12104/42282","http://132.248.9.34/hevila/Actualidadesinvestigativaseneducacion/2011/vol11/no2/14.pdf; http://132.248.9.1:8991/F/T2YHQN5JKYSPCIP3SAPK3TB1KGTDDEFCSVNH496MXCXGEJUB2B-01899?func=full-set-set&set_number=025047&set_entry=000234&format=999",,"Español",,,,"2",,"Actualidades Investigativas en Educación",,"ene-24",,"11",,"CLASE
PERIODICA",,,,,,,,"Psicología educativa",,,"El rendimiento académico de las mujeres en matemáticas","El rendimiento académico de las mujeres en matemáticas: análisis bibliográfico y un estudio de caso en educación superior en México",,"journalArticle" "44125","123456789/35008",,"Alcaraz-González, V., University of Guadalajara - CUCEI, Guadalajara, Jalisco, Mexico; López-Bañuelos, R.H., University of Guadalajara - CUCEI, Guadalajara, Jalisco, Mexico; Steyer, J.-P., INRA, Laboratoire de Biotechnologie de l'Environnement, Narbonne, France; Méndez-Acosta, H.O., University of Guadalajara - CUCEI, Guadalajara, Jalisco, Mexico; González-Álvarez, V., University of Guadalajara - CUCEI, Guadalajara, Jalisco, Mexico; Pelayo-Ortiz, C., University of Guadalajara - CUCEI, Guadalajara, Jalisco, Mexico",,"Alcaraz-Gonzalez, V.
Lopez-Banuelos, R.H.
Steyer, J.-P.
Mendez-Acosta, H.O.
Gonzalez-Alvarez, V.
Pelayo-Ortiz, C.",,"2012",,"Anaerobic digestion (AD) is a highly nonlinear time-varying process commonly used for biological wastewater treatment, which is subject to large disturbances of both influent concentrations, and flow rates that may lead the process to a breakdown. In order to compensate the effect of these disturbances, the dynamics of the main state variables - including biomass - must be closely monitored and used to improve the process performance. However, AD processes still suffer from a lack of reliable and cheap sensors of key process variables to insure the right process operation. This has led to the development of estimation schemes, which infer the information of such key variables from the available measurements. Nevertheless, reliable measurements are not always possible to get because these readings may be corrupted by noise or erroneous due to sensor failures and as a consequence, they may lead to deteriorated control efforts and the eventual crash of the AD process. In this article, we propose an integrated system for the detection, isolation, and analysis of faults in AD processes by using interval observers (IO). The proposed approach was experimentally implemented on a 1-m3 pilot scale anaerobic digester. Based on the comparison between the measured outputs and their corresponding estimates, results show that this approach was able to detect sensor failures as well as faults in the basic hypotheses made during the design step. " 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
URI: http://hdl.handle.net/20.500.12104/42346
http://www.scopus.com/inward/record.url?eid=2-s2.0-84866503295&partnerID=40&md5=fd18c885c939f831281c16361f7ac26f
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